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by Steve Brown
Sat Apr 30, 2016 3:00 pm
Forum: General Discussion Topics and Issues
Topic: Low ascorbic tolerance
Replies: 8
Views: 1214

Re: Low ascorbic tolerance

vibes wrote:...I've reached bowel tolerance on just 20000mg a day...


20000 milligrams is 20 grams. It is not unusual to reach bowel tolerance on a dose that high.
by Steve Brown
Sat Mar 21, 2015 2:53 pm
Forum: General Discussion Topics and Issues
Topic: Owen's Blood Still Clumping
Replies: 169
Views: 30393

Re: Owen's Blood Still Clumping

Due to my overly excessive vitamin C intake... Owen, I've been away from this forum for a few years, just checked back to see what's going on, and was surprised to read the above revelation. I'm curious as to when and why you came to the realization that your vitamin C intake is "overly excess...
by Steve Brown
Wed Jul 31, 2013 6:23 pm
Forum: Linus Pauling's Vitamin C/Lysine Therapy
Topic: Include n acetyl cysteine in the Pauling Therapy?
Replies: 2
Views: 2378

Re: Include n acetyl cysteine in the Pauling Therapy?

As the goal of the Pauling therapy is to reverse the buildup of arterial plaque, anything that has that effect could improve the result. "Patients suffering from osteoporosis were shown to have extensive calcium plaques, which impaired blood flow in the arteries. This simultaneous excess of cal...
by Steve Brown
Thu Feb 07, 2013 4:14 pm
Forum: Archive
Topic: How Does Vitamin C as Ascorbic Acid Enter Cells?
Replies: 48
Views: 32899

Re: How Does Vitamin C as Ascorbic Acid Enter Cells?

Its well known nowdays that C enters the brain via choroid plexus using SVCT2 transporters and via GLUT. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649700/ See 2.1 Routes of ascorbate entry into the CNS Thank you for posting the link to that article, which is from an authoritative source, covers ...
by Steve Brown
Thu Feb 07, 2013 12:36 pm
Forum: Archive
Topic: How Does Vitamin C as Ascorbic Acid Enter Cells?
Replies: 48
Views: 32899

Re: How Does Vitamin C as Ascorbic Acid Enter Cells?

Tracy in the above post is correct. Owen, I'm not a chemist but I have studied chemistry and understand the basics of molecular bonds, acids, bases, salts, oxidation, reduction, and stoichiometry. I'm interested in the biochemistry of vitamin C and that is why I engage in discussions on this forum a...
by Steve Brown
Tue Jan 29, 2013 3:14 pm
Forum: Archive
Topic: How Does Vitamin C as Ascorbic Acid Enter Cells?
Replies: 48
Views: 32899

Re: How Does Vitamin C as Ascorbic Acid Enter Cells?

I am not certain about the mitochronria - (Russell Jaffe in his lectures mentions that Alpha Lipoic Acid is the "natural" antioxidant in the mitochondria, and that vitamin E is the antioxidant generally protecting the cellular membrane, etc.) but again, it makes no common sense that vitam...
by Steve Brown
Fri Jan 25, 2013 2:01 am
Forum: Archive
Topic: How Does Vitamin C as Ascorbic Acid Enter Cells?
Replies: 48
Views: 32899

Re: How Does Vitamin C as Ascorbic Acid Enter Cells?

...especially in light of that paper johnwen cited on ascorbate uptake by liver cells which doesn't even mention glucose uptake. In fact, while "sodium" dependent transporters are involved, the experimenters used ascorbic acid! I think your discussion above helps explain how SDVT work - w...
by Steve Brown
Fri Jan 25, 2013 1:28 am
Forum: Archive
Topic: How Does Vitamin C as Ascorbic Acid Enter Cells?
Replies: 48
Views: 32899

Re: How Does Vitamin C as Ascorbic Acid Enter Cells?

Thank you for running this experiment. And from this, what do you think we can conclude? It would seem that you showed that ascorbic acid can be in the blood at the combination/concentrations found in the blood and not necessarily react with the sodium bicarbonate. What I can conclude from the expe...
by Steve Brown
Fri Jan 18, 2013 8:51 pm
Forum: Archive
Topic: How Does Vitamin C as Ascorbic Acid Enter Cells?
Replies: 48
Views: 32899

Re: How Does Vitamin C as Ascorbic Acid Enter Cells?

It occurred to me that the benefits claimed for taking hydrogen peroxide may be due to it oxidizing some of the vitamin C in a person's system, converting it to dehydroascorbic acid which is readily taken up by cells. If that is the case, my opinion is that it would be safer to react hydrogen peroxi...
by Steve Brown
Wed Jan 16, 2013 1:23 pm
Forum: Archive
Topic: How Does Vitamin C as Ascorbic Acid Enter Cells?
Replies: 48
Views: 32899

Re: How Does Vitamin C as Ascorbic Acid Enter Cells?

"Active transport is the main mechanism of vitamin C distribution within the body. Simple diffusion may occur in the mouth and stomach but accounts for only a very small percentage of uptake (13). Sodium-independent transport systems shuttle vitamin C across the basolateral membrane of the inte...
by Steve Brown
Wed Jan 16, 2013 12:58 am
Forum: Archive
Topic: How Does Vitamin C as Ascorbic Acid Enter Cells?
Replies: 48
Views: 32899

Re: How Does Vitamin C as Ascorbic Acid Enter Cells?

Thinking along the lines of an experiment... The normal range of concentration of bicarbonate ion (HCO3-) in the blood is 22 to 30 millimoles per liter. For our purposes, let's say it's 25 mmol/L. The molar mass of sodium bicarbonate (NaHCO3) is 84 grams per mole. 25 millimoles of NaHCO3 would be 0....
by Steve Brown
Tue Jan 15, 2013 8:10 pm
Forum: Archive
Topic: How Does Vitamin C as Ascorbic Acid Enter Cells?
Replies: 48
Views: 32899

Re: How Does Vitamin C as Ascorbic Acid Enter Cells?

Considering that the uptake of vitamin C by cells is preferentially for dehydroascorbic acid raises two questions in my mind. The first is, what happens to vitamin C when a person's diet is so abundant in antioxidants that there are few free radicals in the blood? One possible answer is that most of...
by Steve Brown
Tue Jan 15, 2013 7:48 pm
Forum: Archive
Topic: How Does Vitamin C as Ascorbic Acid Enter Cells?
Replies: 48
Views: 32899

Re: How Does Vitamin C as Ascorbic Acid Enter Cells?

1. Why did biochemist/exert Sherry Lewin write in Vitamin C: Its Biology and Medical Potential that vitamin C traveled in the blood as ascorbic acid? (And as SA in the lymph?) The statement "vitamin C travels in the blood as ascorbic acid" is true only as long as it does not mean "vi...
by Steve Brown
Mon Jan 14, 2013 6:06 pm
Forum: Archive
Topic: How Does Vitamin C as Ascorbic Acid Enter Cells?
Replies: 48
Views: 32899

Re: How Does Vitamin C as Ascorbic Acid Enter Cells?

I doubt that a molecule of ascorbic acid can exist for long in the bloodstream before reacting with the bicarbonate buffering system and being converted to sodium ascorbate. The concentration of sodium bicarbonate in the bloodstream is many times higher than the concentration of ascorbic acid that c...
by Steve Brown
Tue Jul 24, 2012 6:09 am
Forum: Archive
Topic: Something you wrote 4 years ago.
Replies: 34
Views: 18833

Re: Something you wrote 4 years ago.

I've always had the impression that all vitamin c taken orally (ascorbic,ascorbate) was released into the blood stream as ascorbate. Anyone care to clarify this for me??? The ascorbate ion is the negative portion of the vitamin C molecule. It has the chemical formula C6H7O6-, the "-" indi...

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