I am not paying to see this seminar report,
First Line Comprehensive Care. Part II: Anthropogenic Xenobiotics in Functional Medicine. Managing Persisting Bioaccumulating Pollutants: Toxic Minerals, Biocides, Hormone Mimics, Solvents, and Chemical Disruptors
but there is a good bio of Dr. Jaffe which includes this information:
Russell Jaffe is Senior Fellow of the Health Studies Collegium research foundation. He is developer of various functional methods from occult blood detection in early colon cancer screening to platelet dose–response aggregation studies in coagulation to the LRA by ELISA/ACT tests and plans, the d-penicillamine nutritional and toxic mineral assessment protocol, the ascorbate calibration protocol, magnesium uptake protocol, glutamine recycling protocol, among others. He serves as director of ELISA/ACT Biotechnologies, LLC and, PERQUE, LLC, nutritive supplements.
He is recipient of the International Scientist of the Year 2003 awarded by the International Biographical Commission of Cambridge, England to recognize his contributions to Biochemistry, Clinical Medicine, and Immunomics. He was recently elected as a Fellow of the National Academy of Clinical Biochemistry. He also maintains Fellow status in the American Society for Clinical Pathology, American College of Nutrition, American College for Allergy, Asthma, and Immunology, American Medical Laboratory Immunology, and the Federation of Clinical Immunology Societies. He is also a certified clinical nutritionist (CCN).
Looking for the background on using ascorbate to chelate heavy metals, found this paper,
Managing Toxic Metals, Biocides, Hormone Mimics, Solvents, and Chemical Disruptors
Here is a Townsend Letter article that summarizes Jaffe's presentations (page 22 (5 of PDF)
Metals affect the DNA, messenger RNA, mitochondria, enzymes, hormones, free radicals and the
immune system. Dr. Russ Jaffe has neatly organized a few of the known mechanisms in his lectures. The following list of mechanisms is taken from these lectures.32 The toxicant metals act as: 1) metabolic uncouplers that cause bioelectrical short circuits; or 2) haptens that cause immune sensitizing of small molecules resulting in secondary autoimmunity; 3) enzyme inhibitors that
bind to active sulfhydryl sites; 4) agents for depleting glutathione and ascorbate and agents for decreasing adenosine triphosphate; 5) concentrating agents in the brain’s choroid plexus and kidneys; 6) inhibitors of thiamine (B-1) and pyrodoxine B-6); 7) inhibitors of glutathione binding, which leads to altered brain tubulin, disrupted nerve function and communication; betatubulin
disorders of the brain causing neurofibrillary tangles; 9) inhibitors of nerve cone growth with retrograde degeneration of neurite membrane; 10) the cause of most, if not all, aberrant biochemistry in Alzheimer’s disease brain in the case of mercury;33 11) a toxicant, in the case of mercury, that passes the placental barrier, allowing toxicant metal in the mother to be transferred
to the fetus; 12) an agent that decreases dopaminergic brain activity leading to neurodegeneration. These are 12 mechanisms by which toxicant metals affect our health. Together, Dr. Jaffe and Dr. Deth provide 13 mechanisms of toxicant metals. As more resources are poured into studying the basic mechanisms of toxicant metals, more mechanisms will be forthcoming.
But so far, I cannot find a paper to go with that wonderful video lecture of Dr. Jaffees. How ascorbate chelates heavy metals in the proper amount and environment. Help appreciated.