Russel M. Jaffe - International Scientist of the Year

[ofonorow]

[ofonorow]

Discussion of his background at NIH
D-penicillamine in Toxic Metal Detoxification - Russell Jaffe MD PhD
http://www.youtube.com/watch?v=SY5h6tDF4iw

[ofonorow]

2010 version of the 2009 Jaffee lecture originally posted. This is a better explanation of how/why vitamin C works!

Russell Jaffe, MD, PhD discusses safe detox methods IAOMT 2010 Galloway
http://www.youtube.com/watch?v=8fnfa48mjL8

"Safer removal of toxic metals"

"complexing, mobilizing and safely excreting toxic metals"

"ascorbate loves to scavenge toxic metals.. double valent catons - such as lead, mercury etc will bind to ascorbate.

Original contribution: how much toxic metal can a gram (5 mmol) of ascorbate bind with a toxic metals. Conservative methods find a gram of ascorbate finds 10 mcg of Hg.

Ascorbate is the molecule cells like most... Cells accumlate ascorbate levels 30x over plasma

Typical populaton "calbibrates (ascorbate requirement) more than 10 g, and less than 130 g of ascorbate.

Ascorbate safely protects, mobilizes, complexes, and excretes toxic minerals.

60% in urine, 30% in feces, 10% in sweat

Healthy levels of magnesium/zinc are synergistic and assist ascorbate chelate (He speculates
because these promote a more alkaline state) How many in healthy alkaline state? Very few.

Sulphur sources in diet can help ascorbate (conjegation) toxic metals (lower the burden)

Objective: reduce oxidative stress

Always means buffered form of ascorbate (never acidic form) in this talk

Can find out alkaline status with First Morning Urine. Test for metabolic acidosis. 6.5 to 7.5 is
healthy range.

selenomethionine - the beneficial form of selenium - other forms do not work well.

To enhance extretion - selenomethionine and sulfur rich foods (eggs, onions, garlic, ginger, brassica sprouts)

sulfur rich foods promote GSH store

metalothionein - natures protection for heavy metals - combines with metal, frees mg/zinc, lower levels better.

ascorbate is the most effective way to raise GSH (Alton Miester was right all along) (min 27)

Minute 35 - Ascorbate Calibration method.

Healty - 1.5 g every 15 min
Moderately ill - 3 g every 15 min
Chronically ill - 6 - 12 g every 15 min

for two hours until "evacuation" - contrast with bowel tolerance, slow buildup, which can recirculate toxins! This will flush toxins.

http://www.PERQUE.com - ascorbate calibration procedure

After discussion of Sulphur foods - requirement,

talks about bioflavonoids/polyphenols

Lipoic acid protects the nucleus (antioxidant) (around min 52 )

Discussion why " ascorbate is never a pro-oxidant in biological systems. " (min 53)

[ofonorow]

Here is the same basic Jafee lecture - from 2008 .
Dr. Russell Jaffe discusses using Vitamin C for heavy metal detox IAOMT 2008
http://www.youtube.com/watch?v=yOZo0-vC93I

[randian]

Sulphur sources in diet can help ascorbate (conjegation) toxic metals (lower the burden)

Another use for MSM?

selenomethionine - the beneficial form of selenium - other forms do not work well.

Other than its general dietary properties, what does selenium offer for the detox program Jaffe is talking about?

Ascorbate Calibration method

Is this just a quicker way to find your daily bowel tolerance number?

[Lemonaid]

Selenoproteins have a high affinity with binding to mercury.

[ofonorow]

Good questions.

Sulphur sources in diet can help ascorbate (conjegation) toxic metals (lower the burden)

Another use for MSM?

I am compiling a list of questions for professor Jaffee - and this is a good one, since the implication that the sulfur atom is important. (However, thinking about glutathione - it is composed of 3 aminos, (Glutathione (GSH) is a tripeptide made up of the three amino acids cysteine, glycine and glutamate). The aminos cysteine (and methionine) contain sulfur, yet alone, they do not work like glutathione to attach to toxin and and emerge from the cell (detoxify the cell).

selenomethionine - the beneficial form of selenium - other forms do not work well.

Other than its general dietary properties, what does selenium offer for the detox program Jaffe is talking about?

Good explanation from Lemonaid.

Ascorbate Calibration method

Is this just a quicker way to find your daily bowel tolerance number?

Great question. All these years and just realizing the important distinction.

I have now watched all three of Russell Jaffee's hour-long lectures. Basically the same, (filmed a year apart.) Ascorbate Calibration does determine your requirement, but seems to be an detoxification method.

Dr. Jaffee's specialty is "heavy metal detoxification". His PHD thesis was on this topic. (He says he entered "this" field (vitamin C?) as a skeptic to debunk it.)

What I am understanding is that the concentration and intensity of oral ascorbate determines its ability to "complex", "mobilize" and "safely excrete heavy metal toxins" from the body. Jaffee said that calibration is different than bowel tolerance, because "slowly titrating to tolerance" will allow toxins to recirculate!

The implication is that his intense calibration method (at least 1.5 g every 15 minutes) will not! (Those with chronic illness would take 6-12 g every 15 minutes!)

And you thought our "surefire" cold remedy was intense!

[ofonorow]

[ofonorow]

Of Jaffe's video lectures, this is perhaps the most relevant to this disccusion of whether Dr. Jaffe was for or against ascorbic acid for metal detox.

http://www.youtube.com/watch?v=Ibz0IHGNCCU (2009)

When he says he recommends ascorbate - "uses ascorbate ' found in foods," we can tell by the later discussion that Jaffe is talking about L versus D ascorbate, not ascorbic acid versus sodium ascorbate!

Regarding heavy metal detox.

Says L-ascorbate is the only "divalent cation" - found in nature.

With " vicinal hydroxyls"

Two hydroxyls on the same side of adjacent carbons - unique in nature, only L ascorbate has that

D-ascorbate does not.

"can be used for heavy metal detox with or without the "pulsed chelator" d-penicillamine"

Says references are in physical chemistry, (the affinity the divalent cation has for the various metals mentioned)

J. of Experimental Botany, 2002: 53(272): 1351-1365