http://www.smithsonianmag.com/science-nature/could-deadly-infections-be-cured-vitamin-c-180963843/Very good report on Marik and the raging "debate" in medicine.
A few quotes from the article
Marik is no loose cannon. Even skeptics of his results acknowledge his expertise. He has authored more than 400 medical journal articles and four books, including a critical care textbook—together “an extraordinary contribution to the literature in critical care,” says Dr. Craig Coopersmith, a leading sepsis researcher at the Emory University School of Medicine.
During an interview in his office, Marik called up Dr. Joseph Varon, a pulmonologist and researcher at the University of Texas Health Science Center in Houston. "It does sound too good to be true,” Varon said over the phone. "But my mortality rates have changed dramatically. It is unreal. Everything we have tried in the past didn't work. This works."
Last year, Marik reached out to Dr. John Catravas at nearby Old Dominion University to study how his treatment worked at the cellular level. The two met when Catravas was recruited to the university three years ago, and have stayed in touch. Catravas has spent decades studying endothelial cells, the thin layer that lines blood vessels; patients with sepsis leak blood through the cell walls, causing pulmonary edema and death.
To test Marik's protocol, Catravas and his team cultured endothelial cells from lung tissue and exposed them to the endotoxin found in septic patients. Vitamin C alone did nothing. Neither did steroids. When administered together, however, the cells were restored to normal levels. "We have a clinical answer," Catravas says. "We have part of the mechanistic answer. There is satisfaction in that as a scientist. There is also satisfaction knowing that a lot of people worldwide are going to get an amazing benefit."
As of this week, Coopersmith of the Emory University School of Medicine is involved in planning a national, multi-center trial to test the efficacy of the vitamin C protocol, with funding from the Marcus Foundation. “If this is validated, this would be the single biggest breakthrough in sepsis care in my lifetime,” he says.
Owen R. Fonorow, Follow #OWENRFONOROW at twitter