As Hickey/Roberts commented in their book, CANCER BREAKTHROUGH,
"There was something odd about the results of the vitamin C and cancer experiments Linus Pauling reported in the 1980s: patients lived longer - much longer. Those treated with vitamin C lived an average of four times as long as control patients who did not receive vitamin C. This massive improvement was unparalleled in the history of medicine."
— Cancer Breakthrough, Handbook on Vitamin C Therapy for Patients and Doctors by vitamin C experts Steven Hickey,PhD, and Hiliary Roberts, PhD.
The following observation made by a local medical doctor may be the “secret weapon” that unintentionally improved the effect of vitamin C against cancer in the Pauling/Cameron Scotland study: the addition of sorbitol and cherry flavoring!
I believe I have found more clues to how Cameron’s cancer patients responded better than subsequent patients on IV/C.
While checking about something else, I came across the website of Dr. Arnold Smith of Mississippi. He explains how he had numerous conversations years ago with Dr. Cameron while he was alive. Dr Smith reports something that I never heard of in any of the published literature from that time.
The patients daily took 10g of ascorbic acid orally in large pills, but did not like it. So he and a compounding pharmacist reformulated a different procedure. They drank a solution of sodium ascorbate plus sorbitol plus cherry flavor. Well now!
That means something important to me.
It has recently come to light more and more about the low carbs diet being necessary to beat cancer. OK then, someone drinking something sweet several times daily everyday is going to tend to not crave yet more sweets. This should contribute however inadvertently to a low or lower than average carbs diet and could even be ketogenic since sorbitol is little metabolized and considered a low caloric sweetener. Furthermore, the literature supports a pro-apoptic effect in some tumors.
Next cherry flavor contains significant amounts of benzaldehyde. This substance is notably damaging to tumors by reacting with their precious thiol groups and disrupting thiol-disulfide and redox metabolism. The sodium ascorbate may also have assisted to remove metabolic acids as most cancer patients are moderately acidotic. I have attached some relevant references.
Enjoy! and Merry Christmas!
The following important details are quoted from: Dr. Arnold Smith’s Cancernet at the North Central Mississippi Regional Cancer Center http://cancernet.com/category/immunotheraphy/page/2/ “Ascorbic Acid Mixture” [paragraphs 5, 6 & 7]
Dr. Pauling had suggested to Dr. Cameron that 10 grams of vitamin C daily was a good dose for an initial clinical trial. Dr. Cameron, however, found that patients balked at the 10 large tablets required and often failed to take the recommended dose due to the sheer bulk of medicine. Cameron went to his pharmacist for advice.
The pharmacist suggested a liquid preparation as possibly more acceptable. Conversion of the vitamin C, also known chemically as ascorbic acid, to a non-sour liquid was accomplished by adding baking soda. A form of sugar, sorbitol, was added as a preservative and as a sweetener. A flavor, cherry syrup, was added. Dr. Cameron’s patients in rural Scotland were sent back home with a several week supply of the ascorbic acid mixture, which was typically dispensed in two brown one liter bottles. Refrigeration was recommended. The clinical trial was initiated.
Dr. Cameron reported dramatic improvements in median cancer survival. In addition to much longer survival, some patients experienced protracted remissions. There were survival plateaus observed in cancers, which had been uniformly fatal. Cameron reported his results in the medical literature to a very skeptical and critical audience. Many physicians believed that an assertion that vitamins could treat cancer was ridiculous, and Cameron and Pauling were both subjected to harsh criticism.
SORBITOL VERSUS CANCERS
Quote: 4.Apoptosis. 2000 Apr;5(2):181-7.
Rapid induction of apoptosis in human gastric cancer cell lines by sorbitol.
Teramachi K, Izawa M.
Author information: Department of Biosignaling, Faculty of Medicine, Tottori University, Yonago 683-8503, Japan.
Most solid tumors, including gastric cancers, respond poorly to non-surgical treatments, which are expected to induce an apoptosis-dependent involution. We hypothesize that the apoptotic machinery in solid tumors is either defective or in a suppressed condition. Overcoming the ineffective induction of apoptosis may improve the responsiveness of solid tumors to non-surgical treatments. Recently, sorbitol, a kind of hexose, has been found to be an effective inducer of apoptosis in HEp-2 cells. Therefore, it is of particular interest to examine the effect of sorbitol-treatment on gastric cancer cells. In the present study, we selected 4 gastric cancer cell lines, which have been reported to exhibit different abilities in regard to apoptosis induction, and examined the effect of sorbitol-treatment on apoptosis induction. Within 3 hr after sorbitol-treatment, apoptosis was induced comparably in all cell lines examined. Cell death in MKN-1, MKN-28 or MKN-74 proceeded in a biphasic manner, while cell death in KATO-III was monophasic. The cell death partially depended on caspase activity. Treatments with sorbitol in combination with 12-O-tetradecanoylphorbol-13-acetate (TPA) markedly suppressed the apoptotic cell death, suggesting a role of protein kinase-C-dependent process. To our knowledge, this is the most rapid induction of apoptosis in human gastric cancer cells reported to date. PMID: 11232246 [PubMed – indexed for MEDLINE] 5.
The sugar-free, sweetener xylitol is known to have antibiotic properties and is recommended for healthier teeth. The theory is that microbes accept xylitol is as if it were sugar, but cannot survive.
The osmolyte xylitol reduces the salt concentration of airway surface liquid and may enhance bacterial killing.
Joseph Zabner*†, Michael P. Seiler*, Janice L. Launspach*, Philip H. Karp*, William R. Kearney‡, Dwight C. Look§, Jeffrey J. Smith¶, and Michael J. Welsh*‖**
Abstract: The thin layer of airway surface liquid (ASL) contains antimicrobial substances that kill the small numbers of bacteria that are constantly being deposited in the lungs. An increase in ASL salt concentration inhibits the activity of airway antimicrobial factors and may partially explain the pathogenesis of cystic fibrosis (CF). We tested the hypothesis that an osmolyte with a low transepithelial permeability may lower the ASL salt concentration, thereby enhancing innate immunity. We found that the five-carbon sugar xylitol has a low transepithelial permeability, is poorly metabolized by several bacteria, and can lower the ASL salt concentration in both CF and non-CF airway epithelia in vitro. Furthermore, in a double-blind, randomized, crossover study, xylitol sprayed for 4 days into each nostril of normal volunteers significantly decreased the number of nasal coagulase-negative Staphylococcus compared with saline control. Xylitol may be of value in decreasing ASL salt concentration and enhancing the innate antimicrobial defense at the airway surface.