In all the nonsense about iron "overload" on here, you are the first to mention hepcidin.
It took me a couple of hours on my crummy connection, back when I got into a difference of opinion with Dr Levy on the subject, to find Ganz' original paper.
My contention then and now, is that Dr Levy's fixation on ferritin, and his crude approach to correcting same, are exactly the same as the orthodox obsession with cholesterol, and the equally heavy handed "cures" for that.
Ferritin and cholesterol in these respective cases are simply surrogates reflecting fundamental metabolic control issues.
Mercury is a similar distraction - yes it is not good, but it is not necessary to put up with the brutality and transfer of funds some people think necessary.
The common approaches to "correcting" these are analogous to draining the oil out of your car because it leaks oil - ultimately it WILL stop leaking, but at what cost? An alternative might be to take out the battery or drain the gas - both will stop most oil leaks, since the car won't go.
The approach of adding hormones and such is analogous to constantly adding oil instead of fixing the bloody oil leak - sometimes you must, but it is not fixed, and there may be other disasters approaching that the leak serves warning of.
Blood, 1 August 2003, Vol. 102, No. 3, pp. 783-788
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
A couple more hours to shoot down the good Doctor's Sweat lodge and bloodletting theories as the way to fix it, at least in persons who do not have Hereditary hemochromatosis or similar.
Sweating has been found to have nothing to do with iron excretion - it is not excreted in sweat, but lost in shed skin cells.
I have not been able to find the whole process, and it may not be known, but it seems reasonable that basic body regulatory mechanisms are involved, as in all else.
That would point to getting basic body control functions correct.
This necessarily implies thyroid and adrenal function, and the nutrients that support such.
"Adrenal malfunction is not currently recognized."
Adelle Davis, 1951, 1954, 1965, in the editions I have.
You can figure most of this out with NO OTHER info. It is helpful though to read other stuff.
Following and related posted recently at : viewtopic.php?f=15&t=9773&p=28905#p28905
I want to say that I am astonished and appalled by the general cavalier attitude regarding B vitamins. People are always listing all the stuff they supplement, with a note "a good B multi" or similar. There is no such thing available, and needs vary widely. If B vitamins and basic minerals are correct for the person, much of the voodoo crap disappears. For instance the recent melatonin discussion is irrelevant; correct B and magnesium totally eliminates the need, your body makes what it needs, most precisely.
"1. Low iron (anemia reported on blood tests) for years. Would appreciate a link to the
best/better papers on this link.
>>AD, quick look: Lack of: B6, Mg, E, C, Folic acid, B12, B1, B2, B3(niacin), B5(pantothenic acid), cholin, stomach HCl - dependent on iodine, chloride and all of the preceding, copper, 19 different amino acids
Excess of: stress, drugs, infection
2. Low blood pressure. If I didn't mention it, I was admitted to the Hospital and put in intensive
care the second time (Sept 2011) because of hypotension. Blood pressure was too low in the
>>AD, quick look specific: pantothenic acid, any B vitamin, pantothenic acid, calories, pantothenic acid, protein, pantothenic acid,
"Of all nutrients, however,a lack of pantothenic acid most quickly causes low blood pressure. Since an undersupply of this vitamin inhibits the production of adrenal hormones, excessive amounts of salt and water are excreted and the amount of blood-the volume-actually decreases. Adrenal exhaustion brought on by prolonged stress, which greatly increases the need for pantothenic acid,is invariably accompanied by low blood pressure. Obtaining sufficient pantothenic acid alone often raises the blood pressure to normal."
3. Sodium low. Blood tests
4. Chloride Low. Blood tests
How about some SODIUM CHLORIDE = SALT??? and some pantothenic acid so your adrenals will cause it to be retained???
AD: "Until the blood pressure reaches normal however,salty foods and/or 1/2 teaspoon of salt in water should be taken daily."
FYI, AD statements of low blood pressure results are exactly those of hypothyroid and whole body lack of iodine consequent to iodine deficiency.
Adrenals are in a loop with thyroid; both MUST be attended to.
5. Inflammation and Recurrent Infections
Inflammation means your body is chemically stressed, possibly beyond its immediate coping abilities. Infection means you are beset by alien beings beyond its immediate coping abilities, causing the preceding.
This means your body needs the ammunition to fight off and clean up the problem. This requires huge amounts of nutrients at the best of times. If you also have a polymorphism which interferes with any step of the process, then you need to compensate. Such polymorphisms involving B vitamins are quite common, see BN Ames. They can be hereditary, just like "RA Factor", who'da thunk it?
My theory is that the so called autoimmune diseases are NOT commonly errors of the immune system, but are correct immune responses to malfunctioning body processes. If as in many cases, the immune response uses up the same nutrients of which a deficiency is causing the initial problem, then you get worse fast.
Thus, a healthy person gets an infection, fights it off, depletes something like pantothenic acid or iodine and selenium, which gives the symptoms of that/those deficiency. You feel lousy and go to bed. That relieves the requirements and you recover. With a chronic problem, one class of which is said polymorphisms, you cannot recover without extreme compensation. You go to the Doctor, who hasn't got a clue, and he poisons you, making it worse. Such is the realm of the rheumatologist, and other quacks we have met. The net result of this is that you get worse until they kill you, or you give up and fall in bed long enough to recover a bit because you are doing nothing, especially going to the Doctor.
Alternatively, you could read AD, and Abraham, and Ames, think a little, ask your friends and listen, and you might get better.
Leukocytes concentrate iodine 3-400x, if there is any free in your blood, and use it to kill nasties. If there is none free, they dismantle thyroid hormones to get it. You feel crappy. If they run out of that, they will use chloride instead, but if you avoid salt or piss is out because you have no pantothenic acid, you die.
I have tried to tell you these things before, and I have posted a lot of this info previous.
I have in fact verified this stuff on my own person, it works.