No controversy that statin cholesterol-lowering drugs lower cholesterol.
In my opinion, cholesterol over 250 is elevated, and 440 mg/dl is probably a genetic issue, so yes, if optimal vitamin C does not bring the cholesterol under say 220 (or cut in half) then you are probably in the small subset of the population that is over producing cholesterol for no good reason. But I would begin by trying to "optidose" ascorbic acid powder to bowel tolerance in your case.
Also, I would probably try niacin too before resorting to a statin cholesterol-lowering drug, a drug which is known to interfere with the body's own production of CoQ10. If you resort to statins, or stay on them, take at least 200 mg of CoQ10 daily with meals.
Most people can bring their total cholesterol to 180 mg/dl over time with the optimal daily dosage of vitamin C. I am interested in what happens in your case, from 6 to 12 months on vitamin C. (Assuming there isn't some underlying toxicity issue at play.)
We are flying blind (unfortunately, as no one is studying the Pauling therapy in heart patients) but if I had 2 bypasses, I might be leery of proline. I would begin with high doses of vitamin C, and 5000 to 6000 mg of lysine, and see what happens. (Proline seems to be able to "turn off" the body's production of Lp(a), which in people with healthy arteries and no by--passes is a good thing IFF they are taking vitamin C! (Lp(a) according to the Pauling/Rath theory is a surrogate for chronically low levels of vitamin c in humans.) Bypasses are usually made from leg veins - which I learned from Dr. Levy's STOP AMERICA'S #1 KILLER, are 1-ply (while arteries are 3-ply - or stronger). It is possible that Lp(a) strengthens these veins in heart bypasses, so again,
conservatively without knowing, I would recommend sticking with Pauling's vitamin C and lysine recommendation. (Proline is not essential, meaning our body's make this amino acid.)
Owen R. Fonorow, Follow #OWENRFONOROW at twitter