ofonorow wrote:It is my opinion that for heart disease, chronic scurvy, until it can be proven otherwise, that the absolute number of vitamin C molecules entering the blood is key. The research cited by Pauling in HTLLAFB shows that one molecule of ascorbate is required and used up creating one molecule? (strand?) of collagen.
Coordination of ascorbate with enzyme-bound iron would provide the necessary electrons in uncoupled reaction cycles to reactivate the enzyme (Figure 1), consistent with the observation that ascorbate is consumed stoichiometrically in uncoupled reaction cycles . Thus, the role of ascorbate is to keep the nonheme iron in the catalytically active, reduced state.
ofonorow wrote:Serdana, I'm wondering if this was posted in the wrong topic? That you meant to post or thought you were reading a DHA topic?
The reason for this post is to profer that 6 grams of liposomal might not be equivalent to say 12 grams of ordinary powder, because we are not certain whether the encapsulated vitamin C works its magic on Lp(a)-based plaques.
Furthermore, while we are seeing extraordinary "amplification effects" of True-liposomal versus infection, especially viral infection, so that Dr. Levy estimates from his clinical experience, that True-Liposomal may be 10 times more effective that IV/C directly into the vein - gram for gram.
I don't yet believe such an amplification works visa vis heart disease because at its core, heart disease is a collagen deficiency issue.
The hydroxylation of proline and lysine residues by the collagen hydroxylases is coupled with a stoichiometric decarboxylation of 2-oxoglutarate. Ascorbate is virtually a specific requirement for these enzymes, but previous studies have demonstrated that it is not consumed during most catalytic cycles. Prolyl 4-hydroxylase and lysyl hydroxylase are known also to catalyze an uncoupled decarboxylation of 2-oxoglutarate in the absence of the peptide substrate. It is shown here that, unlike the complete hydroxylation reaction, the uncoupled decarboxylation reaction involves stoichiometric ascorbate consumption.
This stoichiometric ascorbate consumption was also seen when the rate of the uncoupled prolyl 4-hydroxylase reaction was enhanced by the addition of poly(L-proline). Since collagen hydroxylases may catalyze occasional uncoupled reaction cycles even in the presence of the peptide substrates, the main function of ascorbate in these reactions in vivo is suggested to be that of reactivating the enzymes after such uncoupled cycles.
samarkand wrote:I am interested in the debate re Liposomal and ordinary vitamin C powder.
My situation is 2 x 50% blockages and one unexpected recently fitted stent for a 90%+ blockage.
Currently I am taking liquid Liposomal C by DaVinci Laboratories of Vermont. Approx 4000 mg per day - started 2 weeks ago. Plus Lysine and Proline, and a number of other supplements recommended by an alternative MD.