Advanced glycation end products (AGEs)

The discussion of the Linus Pauling vitamin C/lysine invention for chronic scurvy

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gmdodaro
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Advanced glycation end products (AGEs)

Post Number:#1  Post by gmdodaro » Sat Nov 14, 2015 4:46 pm

Here's link to an article I recently found that includes useful information against heart disease.
http://www.lifeextension.com/magazine/2 ... ar/page-01

Block The Aging Effects Of High Blood Sugar
Glycation—the deadly binding of sugars to proteins—produces deadly byproducts called advanced glycation end products (AGEs).
AGEs damage cells, tissues, and organs, and cause premature aging.
Thiamine is the body’s natural defense against AGEs, but since it is water soluble, the body doesn’t absorb it well.
Benfotiamine, a fat-soluble derivative of thiamine (vitamin B1), substantially boosts intracellular thiamine levels, inhibiting the AGEs that cause sugar-related damage to tissue.
Numerous studies demonstrate that benfotiamine blocks the pathways of Alzheimer’s disease, vision loss, cardiovascular disease, and kidney damage.
Benfotiamine is extremely safe and appears to slow the chronic disease and aging effects of glycation in nondiabetic as well as diabetic individuals.

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Re: Advanced glycation end products (AGEs)

Post Number:#2  Post by gmdodaro » Sat Nov 14, 2015 4:49 pm

Benfotiamine Protects Against Cardiovascular Damage
The thin layer of endothelial cells that lines blood vessels constantly regulates blood pressure and flow. Advanced glycation end products damage these cells, which can lead to heart attacks, heart failure, and stroke.54,55

Advanced glycation end products damage blood vessels in three ways:

They reduce endothelial cell replication, a vital process to keep arteries healthy.56
They trigger an increased level of death among endothelial cells.57
They produce toxic polyol compounds, which disrupt the functioning of vascular and endothelial cells.58

Remarkably, studies indicate that benfotiamine protects endothelial cells from all three of these damaging effects of AGEs.56-58 This protection ultimately improves the functioning of blood vessels and heart muscle.59,60

An interesting study on humans revealed just what a dramatic impact these effects would have on heart health. In the study, subjects took 1,050 mg of benfotiamine per day for three days. The scientists wanted to determine the effect benfotiamine would have on the changes in endothelial function and blood flow that occur as a result of consuming a meal rich in advanced glycation end products.59 The striking outcome of supplementation revealed that benfotiamine completely prevented endothelial and blood flow impairment!26,61

Benfotiamine also counters the negative effects of oxidative stress on blood vessels. In a study in which rodents were experimentally induced with vascular endothelial dysfunction, supplemental benfotiamine resulted in improved endothelial integrity and function by enhancement of production of nitric oxide, a compound that helps blood vessels to relax.53,73

Blood sugar and advanced glycation end products greatly contribute to the diminished heart-muscle function known as heart failure, which can be caused by a heart attack or untreated high blood pressure. Scientists have demonstrated that benfotiamine helps normalize the heart muscle’s ability to contract, salvaging damaged heart muscle and improving its capacity to effectively pump blood.60

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Re: Advanced glycation end products (AGEs)

Post Number:#3  Post by gmdodaro » Sat Nov 14, 2015 4:59 pm

Here is another paragraph that got my attention:
Blood sugar and advanced glycation end products greatly contribute to the diminished heart-muscle function known as heart failure, which can be caused by a heart attack or untreated high blood pressure. Scientists have demonstrated that benfotiamine helps normalize the heart muscle’s ability to contract, salvaging damaged heart muscle and improving its capacity to effectively pump blood.60

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Re: Advanced glycation end products (AGEs)

Post Number:#4  Post by Johnwen » Sat Nov 14, 2015 10:31 pm

L-Carnosine does a excellent job at reversing AGE. It takes a while to reach max. effectiveness, however there is good reduction within 24 hours of dosing.
As far as price it's a little on the higher side. 100 pills 500mg. is @ $40.00

I take 500mg 2x a day been doing it for about 3 years. Guess it's doing me good??? Haven't stopped them to see if I feel any difference.

Here's a link to a study on them! PDF File

http://www.pdiconnect.com/content/27/1/86.full.pdf
To steal ideas from one person is plagiarism. To steal from many is
research!

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Re: Advanced glycation end products (AGEs)

Post Number:#5  Post by gmdodaro » Sun Nov 15, 2015 11:23 pm

Thanks, Johnwen!
This looks like a pretty good price for 60 500 mg caps: http://www.swansonvitamins.com/q?kw=carnosine

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Re: Advanced glycation end products (AGEs)

Post Number:#6  Post by Herrybraun » Wed Aug 01, 2018 11:21 am

I really admire your information about AGEs. Thankful to you.

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Re: Advanced glycation end products (AGEs)

Post Number:#7  Post by zarfas » Thu Aug 02, 2018 4:48 am

http://www.peaktestosterone.com/Advance ... _AGEs.aspx

this seems right

Advanced Glycation End Products (AGE's) are basically the nasty byproducts of glucose metabolism. The typical Western Diet, coupled with a sedentary lifestyle, too much fat and insulin resistance, leaves our bodies churning out excess glucose and unable to burn it. It stays in our blood stream too long and there does incredible damage.

One of the most damaging aspects are the Advanced Glycation End Products (AGE's), which includes visible structures such as "liver spots" on the skin to accumulated wastes in various tissues that interfere with normal metabolic processes on the cellular level and lead to Inflammation, one of our sworn arch enemies.

1. Glycemic Load. If you've read anything health-related in the last ten years, you've probably come across an article or two about Glycemic Index. Glycemic Index is just a fancy and rather polite way of telling you that eating a bunch of sugar and starch is bad for you. If you understand that, then you understand the Glycemic Index and don't need to read much from the 40,000 web pages on the subject out there.. I would like to point out that Glycemic Load is a more relevant topic and so I recommend that you keep it in mind.

2. Exercise. Exercise burns calories, lowers insulin resistance and these will in short order stabilize your blood sugar.

3. Fructose. Fructose speeds up Advanced Glycation End Products. One researcher summarized it nicely: "This study demonstrates that long-term fructose feeding accelerates aging as expressed by changes in various age-related markers measured in collagen from skin and bones." [9] The title of another study says it all: "Fructose Ingestion Enhances Atherosclerosis and Deposition of Advanced Glycated End-products in Cholesterol-fed Rabbits" [10] In other words, fructose ages you internally (your arteries) and externally (your skin).

4. Vinegar. Several studies have shown that a tablespoon or maybe two will lower blood sugar levels even after a starchy meal. One study showed, at least in diabetics, improved insulin sensitivity after consumption of vinegar. [4]

5. Cinnamon. One study of diabetics, but keep in mind that most Westerners have blood sugar issues of varying degrees, demonstrated "that intake of 1, 3, or 6 g of cinnamon per day reduces serum glucose, triglyceride, LDL cholesterol, and total cholesterol in people with type 2 diabetes". [5] This is not a lot of cinnamon and would seem like a no-brainer to help defend against Metabolic Disorder, Advanced Glycation End Products (AGE's) and Heart Disease, except for one problem: there is a certain type of "mock" cinnamon (Cassia) that has significant amounts of coumarin, which can be poisonous to the kidneys. You only want to buy true cinnamon, which is Ceylon Cinnamon.

6. Alpha-Lipoic Acid. Again in diabetic patients, alpha-lipoic acid has shined, showing that it reduces glucose levels. Maintenance levels for relatively healthy individucls is typically about 50 mg/day. [6] NOTE: Alpha-lipoic Acid also has another huge benefit: increase one of the body's primary antioxidants, glutathione. For more information, read my link on How to Raise Levels of the Body's Natural Detoxifier.

7. Dietary Fat. Scientists found that rats fed a high fat diet developed cholecystokinin (CCK) resistance. [8] Cholecystokinin, or CCK, sends a signal to the brain, which in turn sends a signal to the liver to decrease glucose (blood sugar) production. A high fat diet sabotages this process, which means increased blood sugar levels for you. In other words, you may think that you are doing your skin good by eating a diet high in fat because you are then avoiding carbs, but this is not the case. I noticed my skin clearing up immediately - yep, smooth as a baby's butt - when I went on a Low Fat Diet for example.

8) Food. Meat and fats cooked at high temperatures actually develop AGE's. Of course, I urge great caution when it comes to meat anyway, since consumption of all the Saturated Fat can lead to many male health and erectile problems. But if you must eat meats, AGE's can be reduced on the grill through various marinades


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