I have high Lp(a) and venous insufficiency. I don’t think the vein issue will resolve as the veins are damaged and probably will not heal. However, I have used the combination of C, L-Lysine and L-Proline in the past to bring down my Lp(a) from the mid-70s to the 30s. I recently re-tested as I knew I needed to get back on the combination and my level is now 97. All other lipids are in a good range. My question is, do you have information on dosing of this product for high Lp(a)?
Any suggestion would be appreciated. Generally, I have kept both Lysine and Proline at about 3-4 grams daily and C at about 12 grams daily but realize that higher doses might be needed and wanted to see what information your group has on the topic.
Thanks and best regards,
My knowledge is that both vitamin C and vitamin B3 (niacin) can lower Lp(a) by 30%, and recently a forum member pointed to Life Extension advice from a recent study that carnitine can lower Lp(a). But do you really want to?
I'm not sure what you mean by "venous insufficiency" but in theory, Lp(a) is acting as a surrogate for low vitamin C intake, shoring up weak blood vessels by helping to create the "plaster casts" of atherosclerosis. So your elevated Lp(a) may be nature's way of trying to deal with your veins.
I think your proline is high, from our experience 1-2 grams (proline is not essential), however, proline is the factor that seems to have the most impact lowering Lp(a). If you do lower it you need to make sure you are getting enough vitamin C! "Enough" can be a very large amount.
Optimal vitamin C would be indicated no matter what. There are at least three methods or measures of the amount of vitamin C a person requires, knowing that many people cannot accept the optimum amount by mouth - they simply cannot absorb what they need.
Total Cholesterol: Optimal 180 mg/dl. The higher your total cholesterol is above 180 mg/dl, the more vitamin C you should be taking. (The GInter references are in Paulings HTLLAVB book).
Bowel Tolerance: See: TITRATING TO BOWEL TOLERANCE https://vitamincfoundation.org/www.orthomed.com/titrate.htm
Russell Jafee Ascorbate Cleanse/Calibration See: http://www.perque.com/lifestyle/self-tests/ascorbate-cleanse/ In a nutshell, you determine the largest one-time dose of vitamin C you can take by mouth without GI issues. Take this amount every 15 minutes until the watery discharge (about 2 hours). 75% of the amount taken is your "calibrated" daily requirement of vitamin C.
In many people, the GI issues are too much, so their only viable option is the liposomal delivery system. Vitamin C is encapsulated in nanometer lipid "capsules" called liposomes, and this promotes absorption during digestion. (Jury is out regarding this delivery mechanism and the Lp(a) Binding Inhibitor effect of the powdered vitamin C and lysine.)