It occurred to me that, once infused into the bloodstream where the EDTA could mobilize the body's iron and copper, that this treatment would likely result in the enhanced oxidation of ascorbate to dehydroascorbic acid. It didn't take any time at all to find a report indicating this is true (4).
ofonorow wrote: Cathcart added EDTA to the stock vitamin C solution to control errant copper and other metal ions - to keep them from reacting with the vitamin C, i.e. EDTA is used as a preservative.
Just thought I'd add a link to a newly published study that is pertinent to this discussion, specifically how EDTA works. Appropriate Handling, Processing and Analysis of Blood Samples Is Essential to Avoid Oxidation of Vitamin C to Dehydroascorbic Acidofonorow wrote:but why would EDTA with iron or copper attached behave differently in the blood?
Although EDTA is an effective metal chelator, complexes with transition metal ions are still redox active, thus its use
as an anticoagulant can facilitate metal ion-dependent oxidation of vitamin C in whole blood and plasma...EDTA anticoagulant samples need to be kept cold at all times during handling, processing and analysis as EDTA-chelated iron is redox active at physiological pH and can facilitate ascorbate oxidation via redox cycling.
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