Daily Mail (UK) article on lp(a)

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Lone Dog
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Daily Mail (UK) article on lp(a)

Post Number:#1  Post by Lone Dog » Fri Mar 30, 2018 4:55 am

I was surprised to see this in a national newspaper, but it's interesting.

http://www.dailymail.co.uk/health/artic ... tacks.html

zarfas
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Re: Daily Mail (UK) article on lp(a)

Post Number:#2  Post by zarfas » Fri Mar 30, 2018 2:01 pm

Lone Dog wrote:I was surprised to see this in a national newspaper, but it's interesting.

http://www.dailymail.co.uk/health/artic ... tacks.html


the article seems very wrong
no where did I see LPA=surrogate for collagen nor vit C
nor lysine/proline niacin, etc


Could pumping your BLOOD through a machine help prevent heart attacks? Scientists believe they've found protein that causes heart disease

Patients are told to reduce cholesterol to lower risk of heart disease and stroke
However scientists now believe the picture is far more complex than that
Study after study points to lipoprotein(a), a fatty particle found in the blood
'Bad' lipoproteins are thought to attach to cholesterol and keep it inside the body

Unlike LDL and HDL cholesterol, the exact role for Lp(a) isn't yet clear, and its levels are not picked up in routine blood tests.

But studies are suggesting that as levels of it rise, so do the risks of cardiovascular disease.

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Re: Daily Mail (UK) article on lp(a)

Post Number:#3  Post by skwoodwiva » Sun Apr 08, 2018 1:49 am

zarfas wrote:
Lone Dog wrote:I was surprised to see this in a national newspaper, but it's interesting.

http://www.dailymail.co.uk/health/artic ... tacks.html


the article seems very wrong
no where did I see LPA=surrogate for collagen nor vit C
nor lysine/proline niacin, etc


Could pumping your BLOOD through a machine help prevent heart attacks? Scientists believe they've found protein that causes heart disease

Patients are told to reduce cholesterol to lower risk of heart disease and stroke
However scientists now believe the picture is far more complex than that
Study after study points to lipoprotein(a), a fatty particle found in the blood
'Bad' lipoproteins are thought to attach to cholesterol and keep it inside the body

Unlike LDL and HDL cholesterol, the exact role for Lp(a) isn't yet clear, and its levels are not picked up in routine blood tests.

But studies are suggesting that as levels of it rise, so do the risks of cardiovascular disease.

It is quite the opposite!

A 2009 paper by the University of Cambridge, published in the journal JAMA, reviewed data and concluded that Lp(a) is a cause of cardiovascular complications such as heart attack, and should be investigated as a target for new treatments.

It then talks of niacin!
The fact that statins boost lpa....
It took a lot of persuading to get my cardio to order a test & it only goes down to 10!
I must be @ 5 now.
On & on

ofonorow
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Re: Daily Mail (UK) article on lp(a)

Post Number:#4  Post by ofonorow » Sun May 20, 2018 6:55 am

One of our employees was just told by her doctor that there is a new drug for lowering Lp(a).
How wonderful for the medical profession.
When I have the name (and cost) I'll post this information.

But this drug would explain the media "attention" to the problem of Lp(a) and this particular article may be designed to make the "noninvasive" drug look better.
Owen R. Fonorow, Follow #OWENRFONOROW at twitter

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Re: Daily Mail (UK) article on lp(a)

Post Number:#5  Post by ofonorow » Mon May 21, 2018 6:56 am

I am pretty sure that the drug is called Inclisiran.



https://clinicaltrials.gov/ct2/show/NCT03397121



Nothing in this mentions Lp(a) - e.g. https://www.forbes.com/sites/johnlamattina/2017/10/26/the-medicine-companys-dangerous-bet-on-its-ldl-cholesterol-lowering-drug/#1c8402601585

Inclisiran achieves LDL lowering of a magnitude similar to that of the PCSK9-inhibiting monoclonal antibodies alirocumab (Praluent) and evolocumab (Repatha), but it will be less expensive to produce and far less costly to administer than the monoclonal antibodies. Dosing is planned to be two or three injections per year, rather than every 2 or 4 weeks, as with the PCSK9 inhibitor monoclonal antibodies, which cost a hefty $14,000 per year. And the sustained efficacy of a dose of inclisiran should make patient adherence to LDL-lowering therapy less of an issue, Dr. Ray continued.

https://www.mdedge.com/ecardiologynews/article/118278/lipid-disorders/video-novel-agent-inclisiran-dramatically-lowers-ldl
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