Do statin drugs mimic a vitamin?

The discussion of the Linus Pauling vitamin C/lysine invention for chronic scurvy

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Ralph Lotz
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Do statin drugs mimic a vitamin?

Post Number:#1  Post by Ralph Lotz » Mon Jan 21, 2008 7:21 am

Do statin drugs mimic a vitamin?

In 2006 Dr. Davis S. Grimes of the Blackburn Royal Infirmary in Great Britain, ruffled a lot of feathers in the medical world when he revealed that statin drugs appear to be synthetic versions (called analogs) of vitamin D. [Lancet 2006 Jul 1; 368(9529):83–6] All the alleged health benefits of statin drugs, prevention of osteoporosis, cancer prevention, promotion of arterial health, parallel those of vitamin D. The pharmaceutical world was quick to deny the allegation.


In his report entitled "Are statin analogs of vitamin D?" Dr. Grimes claims that the concept of statin drugs may come from vitamin D as they appear to be molecular alterations of this vitamin. A more recent study confirms that statin drugs modestly increase vitamin D levels.

From:
Government Health Agencies Complicit in Cholesterol Ruse
by Bill Sardi
http://www.lewrockwell.com/sardi/sardi79.html
"Unless we put medical freedom into the constitution...medicine will organize into an undercover dictatorship..force people who wish doctors and treatment of their own choice to submit to only what..dictating outfit offers." Dr. Benjamin Rush

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Re: Do statin drugs mimic a vitamin?

Post Number:#2  Post by ofonorow » Wed Jan 23, 2008 10:35 am

Does Bill include the molecular diagrams?

I thought that the drug companies patterned statins after vitamin C after reading the 1986 Harwood study, which showed that vitamin C is an HMG CoA Reductaste inhibitor (statin)

Also, I think vitamin D (and vitamin C) work much better than statins, that is, when you take statins your atherosclerotic plaques invariably become "more complex".

Something tells me that vitamins C/D don't have the same issue.
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J.Lilinoe

Re: Do statin drugs mimic a vitamin?

Post Number:#3  Post by J.Lilinoe » Sat Jan 26, 2008 9:49 am

Oh please, I hope that statin drugs don't mimic any vitamin. How dreadful.

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Re: Do statin drugs mimic a vitamin?

Post Number:#4  Post by Ralph Lotz » Sat Jan 26, 2008 10:41 am

Do statin drugs mimic a vitamin?

In 2006 Dr. Davis S. Grimes of the Blackburn Royal Infirmary in Great Britain, ruffled a lot of feathers in the medical world when he revealed that statin drugs appear to be synthetic versions (called analogs) of vitamin D. [Lancet 2006 Jul 1; 368(9529):83–6] All the alleged health benefits of statin drugs, prevention of osteoporosis, cancer prevention, promotion of arterial health, parallel those of vitamin D. The pharmaceutical world was quick to deny the allegation.

In his report entitled "Are statin analogs of vitamin D?" Dr. Grimes claims that the concept of statin drugs may come from vitamin D as they appear to be molecular alterations of this vitamin. A more recent study confirms that statin drugs modestly increase vitamin D levels.
Source: American Journal Cardiology 2007 October 15; 100(8): 1329.

http://www.lewrockwell.com/sardi/sardi79.html
"Unless we put medical freedom into the constitution...medicine will organize into an undercover dictatorship..force people who wish doctors and treatment of their own choice to submit to only what..dictating outfit offers." Dr. Benjamin Rush

Seymore Spectacles

Re: Do statin drugs mimic a vitamin?

Post Number:#5  Post by Seymore Spectacles » Sat Jan 26, 2008 12:41 pm

I don't think the vitamin D mimic theory holds water. If you look at the vitamin D table (found by following Ralph's link), you'll see that the patients receiving a placebo had a much greater increase in vitamin D levels than did the statin users.

This alone seems to suggest the exact opposite of what is being suggested in that part of the article.

Drug Status

Took drug or inactive placebo

Vitamin D level (nanomole/Liter of blood)

No statin
Active 65.9
Placebo 38.4


On statin
Active 74.0
Placebo 50.0

Source: American Journal Cardiology 2007 October 15; 100(8): 1329.


Note that the increase for statin users went from 65.9 to 74. I believe this is about an 11% increase.

The increase in the placebo users went from 38.4 to 50. I believe this is about a 23% increase

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Re: Do statin drugs mimic a vitamin?

Post Number:#6  Post by Ralph Lotz » Mon Jan 28, 2008 8:48 pm

Perhaps this expresses the fact more clearly?
LIPITOR INCREASES VITAMIN D LEVELS
(Atorvastatin is LIPITOR, the best selling drug in history)

Effects of Atorvastatin on Vitamin D Levels in Patients With Acute Ischemic Heart Disease

José L. Pérez-Castrillón MDa, , , Gemma Vega MDa, Laura Abad MDa, Alberto Sanz MDb, José Chaves MDc, Gonzalo Hernandez MDc and Antonio Dueñas MDa
aInternal Medicine Department, Río Hortega University Hospital, Faculty of Medicine of Valladolid, Valladolid, Spain
bPediatric Laboratory, Pediatrics-IBGM Department, Faculty of Medicine of Valladolid, Valladolid, Spain
cPfizer, Madrid, Spain.
Received 20 September 2006; revised 7 November 2006; accepted 7 November 2006. Available online 8 February 2007.



Vitamin D deficiency is a risk factor for osteoporosis and other chronic diseases, including type 1 diabetes, hypertension, metabolic syndrome, and ischemic heart disease. Cholesterol and vitamin D share the 7-dehydrocolesterol metabolic pathway. This study evaluated the possible effect of atorvastatin on vitamin D levels in patients with acute ischemic heart disease. Eighty-three patients (52 men and 31 women) with an acute coronary syndrome (75 with acute myocardial infarction and 8 with unstable angina) were included. After diagnosis, patients received atorvastatin as secondary prevention. Serum vitamin D was measured by high-performance liquid chromatography at baseline and at 12 months. Atorvastatin treatment produced a statistically significant decrease in cholesterol and triglyceride levels and an increase in vitamin D levels (41 ± 19 vs 47 ± 19 nmol/L, p = 0.003). Vitamin D deficiency was decreased by 75% to 57% at 12 months. In conclusion, atorvastatin increases vitamin D levels. This increase could explain some of the beneficial effects of atorvastatin at the cardiovascular level that are unrelated to cholesterol levels.

This study was supported by Pfizer, Madrid, Spain
Last edited by Ralph Lotz on Mon Jan 28, 2008 8:55 pm, edited 1 time in total.
"Unless we put medical freedom into the constitution...medicine will organize into an undercover dictatorship..force people who wish doctors and treatment of their own choice to submit to only what..dictating outfit offers." Dr. Benjamin Rush

J.Lilinoe

Re: Do statin drugs mimic a vitamin?

Post Number:#7  Post by J.Lilinoe » Mon Jan 28, 2008 8:54 pm

Do vitamins mimic the hazardous side effects of statins?
Most likely no, so I hope the researcher's work was thorough.

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Re: Do statin drugs mimic a vitamin?

Post Number:#8  Post by Ralph Lotz » Mon Jan 28, 2008 9:22 pm

The point of my posting "Do statin drugs mimic a vitamin?" is to point out that lowering cholesterol whether by statins or otherwise has no health benefit. Statins have numerous side effects thar are detailed here:

http://www.vitamincfoundation.org/statinalert/

Also if any benefit provided by statinsis that they mimic Vitamin D, or reduce inflammation through another pathway, then why not supplement with 7 cents worth of vitamin D?

Any small benefit of statins has nothing to do with lowering cholesterol, but by reducing inflammation.

Here is a good review from GMS German Medical Science — an Interdisciplinary Journal:
Atherosclerosis, cholesterol, nutrition, and statins – a critical review

http://www.egms.de/en/gms/2007-5/000040.shtml
"Unless we put medical freedom into the constitution...medicine will organize into an undercover dictatorship..force people who wish doctors and treatment of their own choice to submit to only what..dictating outfit offers." Dr. Benjamin Rush


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