Post Number:#6 Post
by Ralph Lotz » Mon Jan 28, 2008 8:48 pm
Perhaps this expresses the fact more clearly?
LIPITOR INCREASES VITAMIN D LEVELS
(Atorvastatin is LIPITOR, the best selling drug in history)
Effects of Atorvastatin on Vitamin D Levels in Patients With Acute Ischemic Heart Disease
José L. Pérez-Castrillón MDa, , , Gemma Vega MDa, Laura Abad MDa, Alberto Sanz MDb, José Chaves MDc, Gonzalo Hernandez MDc and Antonio Dueñas MDa
aInternal Medicine Department, Río Hortega University Hospital, Faculty of Medicine of Valladolid, Valladolid, Spain
bPediatric Laboratory, Pediatrics-IBGM Department, Faculty of Medicine of Valladolid, Valladolid, Spain
cPfizer, Madrid, Spain.
Received 20 September 2006; revised 7 November 2006; accepted 7 November 2006. Available online 8 February 2007.
Vitamin D deficiency is a risk factor for osteoporosis and other chronic diseases, including type 1 diabetes, hypertension, metabolic syndrome, and ischemic heart disease. Cholesterol and vitamin D share the 7-dehydrocolesterol metabolic pathway. This study evaluated the possible effect of atorvastatin on vitamin D levels in patients with acute ischemic heart disease. Eighty-three patients (52 men and 31 women) with an acute coronary syndrome (75 with acute myocardial infarction and 8 with unstable angina) were included. After diagnosis, patients received atorvastatin as secondary prevention. Serum vitamin D was measured by high-performance liquid chromatography at baseline and at 12 months. Atorvastatin treatment produced a statistically significant decrease in cholesterol and triglyceride levels and an increase in vitamin D levels (41 ± 19 vs 47 ± 19 nmol/L, p = 0.003). Vitamin D deficiency was decreased by 75% to 57% at 12 months. In conclusion, atorvastatin increases vitamin D levels. This increase could explain some of the beneficial effects of atorvastatin at the cardiovascular level that are unrelated to cholesterol levels.
This study was supported by Pfizer, Madrid, Spain
Last edited by
Ralph Lotz on Mon Jan 28, 2008 8:55 pm, edited 1 time in total.
"Unless we put medical freedom into the constitution...medicine will organize into an undercover dictatorship..force people who wish doctors and treatment of their own choice to submit to only what..dictating outfit offers." Dr. Benjamin Rush