Question regarding the rebound effect

Any adverse effects of replacement vitamin C will be discuseed here. Topics include kidney stones, gall stones, oxidation, etc.
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Question regarding the rebound effect

Post Number:#1  Post by BimLanders » Wed Oct 11, 2006 11:35 pm

I've read of a condition where, if one were to stop his dose of Vitamin C for one day, he would suffer from "rebound scurvy." I don't worry about this effect at all, as I'm diligent enough to take my high dose every day. However, a friend of mine, who is in good health, expressed interest in Vitamin C. I somewhat strained to recommend a dosage for him, as I'm probably unqualified to answer. I take anywhere from four to six grams a day; I'm in good health, but suffer from allergies. I find that six grams a day pretty much keeps my allergies at bay. For this I am most grateful and am recommending Vitamin C to those close to me.

However, this friend is afraid of the reboud effect. What I told him was this: "I don't know how high your dose would have to be for you to suffer from a rebound effect." For example, if he took only two grams a day, and then skipped a day, would he suffer a rebound effect? If not, what dose would be high enough to trigger this condition?

He should just not miss a day; that much is obvious, but I can't force people to take their vitamins. Even my girlfriend skips days. I pretty much forced her to start taking them as she has slightly high blood pressure, and she easily stresses out.

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Thanks for Posting

Post Number:#2  Post by ofonorow » Thu Oct 12, 2006 10:17 am

A complete discussion of the "discontinuation effect" (sometimes called the rebound effect) was here, may still be here, otherwise I'll try to find it for the archives.

In a nut shell, the Bowel Tolerance forum - and the paper by Cathcart helps people determine what the right amount of vitamin C is for themselves. The answer is somewhere between 4000 mg and 20,000 mg, spread out 4 times throughout the day.

Most people live in a state of vitamin C starvation. A good analogy is the body's response to little water in a desert, the body begins to hold on to its water during periods of dehydration.

Vitamin C is handled in the same way. The body holds on to what little it can get. But, when the supply is ample - such as the case with most animals producing 24/7 - the body no longer needs to horde vitamin C and various enzyme systems begin that transform ascorbate into other substances.

If the supply is then suddenly cut off, these enzyme systems still transform C for 24 to 48 hours, and this is the discontinuation effect. It is not known to be serious, but a cold or congestion is likely.

Pauling recommended not stopping vitamin C even for a single day. I agree. But you can also lower the dosage slowly to avoid this effect.
Owen R. Fonorow, Orthomolecular Naturopath
My statements have not been evaluated by the Food and Drug Administration. Any product mentioned is not intended to diagnose, treat, cure or prevent any disease.”

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