I have had atopic eczema all my life, and having tried vitamin C on the skin and orally in large doses, unfortunately I found no effect, good or bad. There are essentially two types of eczema: atopic eczema, often associated with asthma, that appears to be genetic and seems to run in families (my mother and my daughter have it), and eczema that is caused by the skin becoming sensitised to some irritant. Atopic eczema is hard to cure, being genetic. I have found that heat or cold affect it, but I've never found any underlying cause. The other form of eczema can be cured, by removing the irritant. As Owen pointed out, the irritant may come from inside when the body is trying to detox, but when the detox is over the skin should clear up. For an atopic eczema sufferer who is in otherwise reasonable health, taking supplements won't bring about any improvement because the skin is just 'like that', and that was my experience, until recently, when I started a combination of acupuncture and chinese herbs. I hoped it would work, but was very sceptical for the reasons given above. I have been amazed that many areas of skin have cleared up, notable those that appeared over the last decade or so, leaving me with the stubborn areas behind the knees and in the elbows still bad - but that was what I was born with. I'm still continuing with the treatment, so it is not over yet.