I think you need to maintain your 25-hydroxyvitamin D levels above 30 ng/mL. For my patients and for me personally, I like for it to be between 40-60 ng/mL or 25-hydorxyvitamin D to guarantee vitamin D sufficiency and its health benefits.
It is essentially impossible to get an adequate amount of vitamin D from dietary sources on a daily basis. We have always depended in the past on sensible sun exposure as the major source of vitamin D which we have now abandoned.
Teenagers and adults need a total of at least 2,000 IU of vitamin D a day. Taking 14,000 IU of vitamin D weekly or 50,000 IU of vitamin D every two weeks has been should to be effective in maintain the blood levels above 30 ng/mL in teenagers and adults.
Ralph and other experts are sure to chime in.
Ralph Lotz wrote:Ralph and other experts are sure to chime in.
Owen's vitamin A and D comments are accurate.
However, using large doses of any substances, even orthomolecular ones that appear not to be immediately toxic is a form of chemotherapy, and should be used prudently.
Nutrients, minerals and phytochemicals at even very low levels have a profound effect on genetic expression, activating and/or silencing the genes that direct the synthesis of the millions of proteins that keep us alive and healthy.
Why use a hydrogen bomb if a flyswatter works?
Dr. Rath has proven that nutrient synergy works in over 102 published studies.
Based on my personal lifelong combat with HSV-1, HSV-2 and Herpes Zoster, vitamin C, Lysine and vitamin D3 (start with 50,000 IU until infection subsides) are at the top of the list. Effective virus killing helpers are quercetin, green tea, myrecetin and kaempferol, and eating apples, red onions, berries, broccoli and tea along with the supplements has worked miracles for me.
Recently I discovered a supplement called Nutracidin from VRP, which should really kick viruses in the butt:
Toxicity of vitamin D 300 ng but selected 100 ng to be prudent – Aug 2008
Pharmacokinetics of vitamin D toxicity.
by: Glenville Jones
The American journal of clinical nutrition, Vol. 88, No. 2. (August 2008)
Although researchers first identified the fat-soluble vitamin cholecalciferol almost a century ago and studies have now largely elucidated the transcriptional mechanism of action of its hormonal form, 1alpha,25-dihydroxyvitamin D(3) 1alpha,25(OH)(2)D(3), we know surprisingly little about mechanisms of vitamin D toxicity. The lipophilic nature of vitamin D explains its adipose tissue distribution and its slow turnover in the body (half-life approximately 2 mo). Its main transported metabolite, 25-hydroxyvitamin D(3) 25(OH)D(3), shows a half-life of approximately 15 d and circulates at a concentration of 25-200 nmol/L, whereas the hormone 1alpha,25(OH)(2)D(3) has a half-life of approximately 15 h. Animal experiments involving vitamin D(3) intoxication have established that 25(OH)D(3) can reach concentrations up to 2.5 mumol/L, at which it is accompanied by hypercalcemia and other pathological sequelae resulting from a high Ca/PO(4) product. The rise in 25(OH)D(3) is accompanied by elevations of its precursor, vitamin D(3), as well as by rises in many of its dihydroxy- metabolites 24,25(OH)(2)D(3); 25,26(OH)(2)D(3); and 25(OH)D(3)-26,23-lactone but not 1alpha,25(OH)(2)D(3). Early assumptions that 1alpha,25(OH)(2)D(3) might cause hypercalcemia in vitamin D toxicity have been replaced by the theories that 25(OH)D(3) at pharmacologic concentrations can overcome vitamin D receptor affinity disadvantages to directly stimulate transcription or that total vitamin D metabolite concentrations displace 1alpha,25(OH)(2)D from vitamin D binding, increasing its free concentration and thus increasing gene transcription. Occasional anecdotal reports from humans intoxicated with vitamin D appear to support the latter mechanism.
Although current data support the viewpoint that the biomarker plasma 25(OH)D concentration must rise above 750 nmol/L to produce vitamin D toxicity, the more prudent upper limit of 250 nmol/L might be retained to ensure a wide safety margin.
I am curious about your recommendation of 50,000 IU of Vitamin D. Can you expand? I have never seen a recommendation that high for Vitamin D. Isn't 20,000 IU considered the ceiling?
Ralph Lotz wrote:I am curious about your recommendation of 50,000 IU of Vitamin D. Can you expand? I have never seen a recommendation that high for Vitamin D. Isn't 20,000 IU considered the ceiling?
50,000 IU - 200,000 IU daily for a few days is known as "stoss" therapy in Europe. These amounts are used at the outset of an infection and are not routine everyday doses. If these doses don't show relief of symptoms in 3 days, D3 is not the answer. Such large doses of D3 may increase induced expression of the human cathelicidin antimicrobial peptide (CAMP) gene. Cathelicidin
is an important part of our innate immune system.
5,000 IU is my routine daily dose.
I have 4 grown children and 4 grandchildren. 3 of them are health professionals. We all use stoss therapy when needed, and have for years.
http://www.google.com/search?q=stoss+th ... =firefox-a
Can you get the same effect using a U-V tanning bed for three straight days for a certain duration?
Ralph Lotz wrote:Can you get the same effect using a U-V tanning bed for three straight days for a certain duration?
I think that you would fry yourself.
Buy the pills here:
http://www.lifespannutrition.com/produc ... itamin%20D
http://www.applehealthfoods.net/shop/pr ... _product=1
I reached my bowel tolerance level @ 22g. Do I maintain a daily dose of 20-21g forever? I also take 3000mg of L-Lysine and 6000 IU of Vitamin D. Do I need to increase my L-Lysine?
ofonorow wrote:I reached my bowel tolerance level @ 22g. Do I maintain a daily dose of 20-21g forever? I also take 3000mg of L-Lysine and 6000 IU of Vitamin D. Do I need to increase my L-Lysine?
Regarding tanning bed - if UV/B then probably a good idea, but I am sure that tanning beds also include UV/A (which tans!) and so Ralph is probably right! UV/B spectrum is what causes skin to turn cholesterol into vitamin D.
As far as vitamin C bowel tolerance - this can change as the underlying stress is resolved. So probably not forever, unless you are fighting a toxic load or long term infection, etc. Good idea to keep at bowel tolerance until resolved, and according to Cathcart's chart, most people who are not sick or under stress fall into a range of much less.
ofonorow wrote:Yes, although if it is only suppressed, and not eradicated, then the tolerance might not change. Forgive me, did we recommend http://www.orthomed.com/titrate.htm? Worth reading.
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