You can cool it but don't cool it below room temperature because I'm almost sure low temperature destroy liposomes.
Are you saying it needs to be consumed whilst still warm? Don't put in the fridge at all? What's the basis for this?
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You can cool it but don't cool it below room temperature because I'm almost sure low temperature destroy liposomes.
At first boil over distilled water and pour 310g of it to glass jar. Let to cool it to about 50C (122F). Dissolve 120g of AA in it
norma67 according to this document "Influence of temperature on the manufacturing of liposomes" (http://www.pharmtech.tu-bs.de/files/mue ... le0110.pdf) the transition face
of pure lipids (phospatidylcholine) is 41.4 C and the upper limit (Krafft) point of lecithin (none pure lipids) is 58 C.
Should we aim for 58 C when melting the lecithin instead?
The document states: "For the formation of liposomes a certain temperature
between 41.4 °C and 58 °C is necessary"
Does this mean that we should mix in the ascorbic acid solution at this temperature in the water bath and keep it there for a while
or should we aim for that temperature range when doing the sonification?
The preparation of the liposomes already occurs with cooling below 40 ° C, called the transition temperature, the point where the phospholipids pass from liquid crystal to gel and the liposomes are formed spontaneously.
When the solution has reached room temperature, it is a shiny and viscous gel.
I don't use the blender at all.
I leave it for a few hours in the fridge before I put it in the ultrasonic bath
The ultrasonic bath serves to to decrease the size of the vesicles, to make them smaller. I leave it in the ultrasonic bath (mine is 38kHz 100watt) for 20-30 min, in a water bath at room temperature.
testingc wrote:You can cool it but don't cool it below room temperature because I'm almost sure low temperature destroy liposomes.
Are you saying it needs to be consumed whilst still warm? Don't put in the fridge at all? What's the basis for this?
At first boil over distilled water and pour 310g of it to glass jar. Let to cool it to about 50C (122F). Dissolve 120g of AA in it
No, it is not advisable to add the C vitamin into the water at 50°C, since it is sensible to the temperature.
this is why I add the C vitamin solution (room temperature) to the lecithin solution when this one is at 42°C- 45 °C, just above the transition temperature, in a way to affect the C vitamin as less as possible to the temperature.
I think it's really dangerous for your ears to sonorize and mix the solution. Thats why I prefere this method.
-The Liposome size is important. The too small vesicles do not contain adequate levels of nutritious substance (such as Vitamin C), while the oversized vesicles are not absorbed properly by the membrane, so the nutritious substance is not transported through the intestinal mucosa. the optimum range is of 100-400 nanometers to balance the capacity of nutrition substances and absorption.
-Sonicated liposomes with a more heterogeneous size, generally showed a lower uptake in the liver and in the spleen and the highest level of absorption in the blood in comparative with liposomes less heterogeneous.
Kasia wrote:hello,
I want to ask about alcohol in the mixture- does it stay in the final product? Do kids can use it?
gtrkiwi wrote:Hi all. I have been playing around with the various methods of producing lipo C for some time now and despite my best efforts never seem to be able to produce a brew that doesn't react to the baking soda test.
gtrkiwi wrote:With my last mix I cold mixed all the ingredients and heated in the microwave stopping every 30 seconds to check the temp. Did this all the way to 50 deg Celsius at which time I stirred while allowing to cool. I rightly or wrongly thought the microwave may have the same effect as ultasound albeit at a very different frequency. Any thoughts on this.
gtrkiwi wrote:I am using NOW Sunflower lecithin which I am told is very high quality.
gtrkiwi wrote:I have just tried the heat method and find that in fact the bicarbonate of soda does not react when you drip it on the mix, but if you give it a bit of a stir up it starts fizzing away all the way through.
gtrkiwi wrote:I rightly or wrongly thought the microwave may have the same effect as ultasound albeit at a very different frequency. Any thoughts on this.
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