Telomere Timebomb

[ofonorow]

Thank you tjohnson_nb. Excellent overview. Some points I am mulling over.

The connection between resveratrol and calorie-restriction was interesting!

I thought they may have confused the term "aging" with "life span" during the discussion of the antioxidant experiments.

The idea that the childhood aging disease progeria was not telomere shortening - but an abnormal protein was also interesting. Wonder if that has been confirmed.

The centenarians was an interesting segment, and in addition to their 3 genes, one wonders if their intracellular glutathione levels were higher - as per Levy's GSH MASTER DEFENDER revelations.

[ofonorow]

Another candidate to promote anti-aging/rejuvenation - AMKP enzyme stimulators.
http://www.lef.org/Magazine/2014/SS/AMPK/Page-01

[ofonorow]

https://www.youtube.com/watch?v=GzrMEgl2DZ0
Bruce Ames refers to Tomas Prolla's work. This video on calorie restriction - trying to understand it - is fascinating. Near the end they report the finding that intracellular glutathione (GSH) universally (all tissues) at least DOUBLES under calorie restriction.

leads to
Short-term consumption of a resveratrol-containing nutraceutical mixture mimics gene expression of long-term caloric restriction in mouse heart.
http://www.ncbi.nlm.nih.gov/pubmed/18657603

and to


Gene Expression Profiling of Aging in Multiple Mouse Strains: Identification of Aging Biomarkers and Impact of Dietary Antioxidants
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733852/

We also tested the ability of dietary antioxidants to oppose these transcriptional markers of aging. Lycopene, resveratrol, acetyl-L-carnitine, and Tempol were as effective as caloric restriction in the heart, and ?-lipoic acid and coenzyme Q10 were as effective as caloric restriction in the cerebellum. These findings suggest that transcriptional biomarkers of aging in mice can be used to estimate the efficacy of aging interventions on a tissue-specific basis.

[xor2]

What does this: HTLLAFB mean?

[tjohnson_nb]

How To Live Longer .... by Pauling

[ofonorow]

[ofonorow]

[ofonorow]

Scientists map elusive 3-D structure of telomerase enzyme, key actor in cancer, aging
http://newsroom.ucla.edu/releases/breakthrough-3-d-structure-of-245100

[ofonorow]

[Johnwen]

Owen;

Here some links that may help for the testing.

http://telomeraseactivation.blogspot.co ... sting.html

http://www.telome.com/index.php

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045570/

Some of these prices are high, but hay! they got to deal with spit in a cup! So I guess it's the high price of dealing with YUCK!

[ofonorow]

[Johnwen]

It appears what their saying is that it don't slow aging but enhances Healthy Aging. Which isn't all that bad either!
I included Bill Andrews video (part 1 there is a link to Pt.2) of him talking about it. I didn't watch it probably tomorrow?? The other link gives an assessment of Ta-65 and the last one is the work Hf Valenzuela whose one of the author's of the previous article and his other works.

Hope this helps!

http://ta65review.org/dr-bill-andrews-o ... ocess-pt-1

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972662/

http://www.ncbi.nlm.nih.gov/pubmed?cmd= ... zuela%20HF[au]&dispmax=50

[ofonorow]

Terrific links, again thank you johnwen. What I think by what LEF initially told me, is that the telomere tests are so specialized that they required a doctor with knowledge of the results? In a way admitting that their staff can't handle the telomere measurement results. And perhaps there is some fear, maybe with the new Federal laws, of offering these tests.

They do call themselves "Life Extension" and could hire a physician who can evaluate the results, we would hope.

With this in mind, and the idea of "crowds" perhaps having an effect, if readers of this topic were to take action, they may begin to see the value in offering such blood tests!

So good readers, why not contact Life Extension and ask why they aren't offering telomere length lab measurments - even saliva telomere testing?

Here is the link I used http://www.lef.org/quest-com (there is a contact/email button at the bottom, but you may have to be a member. Worth tying to send the email question, even if you are not already a member.)

Thanks to all crowd participants in advance!

[Johnwen]

[ofonorow]

Thanks again johnwen!

Speaking of knowledge, I am in the middle of Blackburn's book Telomeres (http://www.amazon.com/Telomeres-Cold-Spring-Harbor-Monograph/dp/0879698101/ref=sr_1_3?ie=UTF8&qid=1420392696&sr=8-3&keywords=telomeres+blackburn) This book is not for those trying to get their feet wet, rather it is by the primary researcher aimed at other researchers and classrooms. As Spock might say, Fascinating!