My thoughts after six months on high dose cycloastragenol.
Per the TrifecTA study, my wife and I had our follow-up after 3-4 months - and her shortest telomeres lengthened greater than the +/- error given on the report. (Mine stayed the same, but I weigh more than my wife.)
The next follow-up will be at the end of August - and will include one lady with very short telomeres who increased her dosage (after seeing her first scores) to what I am now taking - 100 mg daily. So she weighs less and is now taking double the dosage. It will be interesting.
Here are some thing I think I have learned.
1. Telomerase is only active (as is all DNA repair) during the so-called S-phase (synthesis) of cell division where the DNA is copied. This may explain some of the delayed measurement response. Ordinary cells that are measured won't have longer telomeres unless they are the daughter cell of a cell division. In other words, having telomerase expressed (present) in a cell that hasn't divided is a noop.
2. Telomeres have been studied in microorganisms, plants, higher level organisms and humans, and all these experiments and findings point to the fact that telomerase is "recruited" via a series of proteins to the shortest telomeres in the cell. Telomerase preferentially elongates the shortest telomeres, which is why this effect is the focus of our study.
3. We have experienced almost all the effects that Ed. Park writes about in Telomere Timebombs, include the vivid dreaming, change in sleep patterns, etc. And then some, probably caused by the PLC (liposome material) and extra ingredients (additional effects, including increased libido)
4. I was hoping for more obvious signs of age reversal, such as hair darkening, but while I feel good, I don't notice any rejuvenation. And even with the Ames Acetyl-L-carnitine and alpha lipoic acid, this has not happened in six months. From my reading on telomeres, any experiments that show rejuvenation from lengthening telomeres only occurs when the telomeres are critically short. If medium telomeres are made longer, there is not much effect in the experiments, and I don't expect much of a rejuvenation effect. (There is an issue of gene expression suppressed by telomeres as they curl back over the DNA, so keeping them longer than 8000 KB appears now to be optimum.)
The objective is to extend life. To push out the crisis caused by short telomeres.
Owen R. Fonorow, Orthomolecular Naturopath
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