Telomere extension turns back aging by decades in vitro

Discussion of the 2009 Noble Prize in Medicine, focusing on substances that reduce telomere shortening by activating the human telomerase enzyme

Moderator: ofonorow

ofonorow
Ascorbate Wizard
Ascorbate Wizard
Posts: 15822
Joined: Tue Nov 22, 2005 3:16 pm
Location: Lisle, IL
Contact:

Telomere extension turns back aging by decades in vitro

Post Number:#1  Post by ofonorow » Tue Feb 03, 2015 4:24 pm

Telomere extension turns back aging by decades in cultured human cells
http://nextbigfuture.com/2015/01/telomere-extension-turns-back-aging-by.html


The researchers found that as few as three applications of the modified RNA over a period of a few days could significantly increase the length of the telomeres in cultured human muscle and skin cells. A 1,000-nucleotide addition represents a more than 10 percent increase in the length of the telomeres. These cells divided many more times in the culture dish than did untreated cells: about 28 more times for the skin cells, and about three more times for the muscle cells.

“We were surprised and pleased that modified TERT mRNA worked, because TERT is highly regulated and must bind to another component of telomerase,” said Ramunas. “Previous attempts to deliver mRNA-encoding TERT caused an immune response against telomerase, which could be deleterious. In contrast, our technique is nonimmunogenic. Existing transient methods of extending telomeres act slowly, whereas our method acts over just a few days to reverse telomere shortening that occurs over more than a decade of normal aging. This suggests that a treatment using our method could be brief and infrequent.”
Owen R. Fonorow
HeartCURE.Info
American Scientist's Invention Could Prevent 350,000 Heart Bypass Operations a year

ofonorow
Ascorbate Wizard
Ascorbate Wizard
Posts: 15822
Joined: Tue Nov 22, 2005 3:16 pm
Location: Lisle, IL
Contact:

Re: Telomere extension turns back aging by decades in vitro

Post Number:#2  Post by ofonorow » Wed Feb 04, 2015 5:38 am

Owen R. Fonorow
HeartCURE.Info
American Scientist's Invention Could Prevent 350,000 Heart Bypass Operations a year


Return to “Telomeres”

Who is online

Users browsing this forum: No registered users and 11 guests