TERRA RNA regulates telemore length

Discussion of the 2009 Noble Prize in Medicine, focusing on substances that reduce telomere shortening by activating the human telomerase enzyme

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TERRA RNA regulates telemore length

Post Number:#1  Post by ofonorow » Fri Nov 06, 2015 8:24 am

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323371/
Role of TERRA in the Regulation of Telomere Length

Telomeres have been considered to be transcriptionally silent, but it was recently demonstrated that mammalian telomeres are transcribed into telomeric repeat-containing RNA (TERRA). TERRA, a long non-coding RNA, participates in the regulation of telomere length, telomerase activity and heterochromatinization. The correct regulation of telomere length may be crucial to telomeric homeostasis and functions. Here, we summarize recent advances in our understanding of the crucial role of TERRA in the maintenance of telomere length, with focus on the variety of mechanisms by which TERRA is involved in the regulation of telomere length.
Owen R. Fonorow, Follow #OWENRFONOROW at twitter

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