TRT to increse telomerase activity?

Discussion of the 2009 Noble Prize in Medicine, focusing on substances that reduce telomere shortening by activating the human telomerase enzyme

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zarfas
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TRT to increse telomerase activity?

Post Number:#1  Post by zarfas » Sat Jan 07, 2017 12:53 am

http://www.peaktestosterone.com/Telomeres.aspx

and
Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells
http://www.bloodjournal.org/content/114 ... ecked=true



Just keep that estradiol in check, as that is what causes prostate cancer

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Re: TRT to increse telomerase activity?

Post Number:#2  Post by RatherBeUnknown » Thu Mar 09, 2017 9:12 am

No person has become younger from trt though perhaps a little bit younger looking, so as with nutrients trt only slows aging.
It is in fact not androgens but estrogens that activate telomerase, and do many other things like protect against various forms of heart disease, and thus slow aging.

zarfas
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Re: TRT to increse telomerase activity?

Post Number:#3  Post by zarfas » Thu Mar 09, 2017 1:40 pm

RatherBeUnknown wrote:No person has become younger from trt though perhaps a little bit younger looking, so as with nutrients trt only slows aging.
It is in fact not androgens but estrogens that activate telomerase, and do many other things like protect against various forms of heart disease, and thus slow aging.

you can't get younger..that would require time travel

you can get healthier though :x

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Re: TRT to increse telomerase activity?

Post Number:#4  Post by RatherBeUnknown » Fri Mar 10, 2017 5:54 am

zarfas wrote:
RatherBeUnknown wrote:No person has become younger from trt though perhaps a little bit younger looking, so as with nutrients trt only slows aging.
It is in fact not androgens but estrogens that activate telomerase, and do many other things like protect against various forms of heart disease, and thus slow aging.

you can't get younger..that would require time travel

you can get healthier though :x

Semantics. Of course you can get younger, you can lose the signs of aging and have your cells be like they are in a 20 year old person. 24 is the youngest you can get.

zarfas
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Re: TRT to increse telomerase activity?

Post Number:#5  Post by zarfas » Fri Mar 10, 2017 8:21 am

RatherBeUnknown wrote:
zarfas wrote:
RatherBeUnknown wrote:No person has become younger []from trt though perhaps a little bit younger looking, so as with nutrients trt only slows aging.
It is in fact not androgens but estrogens that activate telomerase, and do many other things like protect against various forms of heart disease, and thus slow aging.

you can't get [b]younger
..that would require time travel

you can get healthier though :x

Semantics. Of course you can get younger, you can lose the signs of aging and have your cells be like they are in a 20 year old person. 24 is the youngest you can get.


funny though
why do you say 24?


trt has, increasing testostrone from low to higher, has shown to increase teleomerase activty(adding TTAGGG sequences to the end of existing chromosomes, right?),

why do you say estrogen? does s##t? it is required, you need estrogen..bones, skin. etc but why do you deny TRTs use?
estrogen cases prostate cancer and even the FDA says it is carcinogenic when too high

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Re: TRT to increse telomerase activity?

Post Number:#6  Post by RatherBeUnknown » Fri Mar 10, 2017 11:56 am

zarfas wrote:
RatherBeUnknown wrote:
zarfas wrote:you can't get younger..that would require time travel

you can get healthier though :x

Semantics. Of course you can get younger, you can lose the signs of aging and have your cells be like they are in a 20 year old person. 24 is the youngest you can get.


funny though
why do you say 24?


trt has, increasing testostrone from low to higher, has shown to increase teleomerase activty(adding TTAGGG sequences to the end of existing chromosomes, right?),

why do you say estrogen? does s##t? it is required, you need estrogen..bones, skin. etc but why do you deny TRTs use?
estrogen cases prostate cancer and even the FDA says it is carcinogenic when too high

Increasing telomerase or telomere length does not mean it prevents telomere cell senescence. 24 is the age cellular senescence begins, or around that age at least. You can only reverse your aging to the beginning of cellular senescence.

zarfas
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Re: TRT to increse telomerase activity?

Post Number:#7  Post by zarfas » Sat Mar 11, 2017 2:59 am

RatherBeUnknown wrote:Increasing telomerase or telomere length does not mean it prevents telomere cell senescence. 24 is the age cellular senescence begins, or around that age at least. You can only reverse your aging to the beginning of cellular senescence.


LOLZ
ok I'm done here


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