CORTISOL - The Perfect Fish Food

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CORTISOL - The Perfect Fish Food

Post Number:#1  Post by ofonorow » Fri Apr 13, 2018 2:47 am

Cortisol: The Perfect Fish Food
(Total Revision DRAFT #3)

© Owen R Fonorow, 2018


“That cortisone and cortisol are normal hormones of the adrenal cortix implies that in physiologic dosages they must be safe” – William Mck Jefferies, Safe Uses of Cortisol. 3rd Edition, 2003


“Our hypothesis, contrary to almost all medical opinion on this matter, is that every symptom of disease that a human being experiences, including chronic pain, is entirely predictable. Symptoms vary based upon blood levels, more specifically tissue levels, of the adrenal hormone cortisol.” – Owen Fonorow, Vitamin C Foundation


Our blood cells: What they need, why they need it, and when they need it

Think of cells as little fish in their big red ocean of blood. There are trillions of these fish, so many cannot move. These fish have multiple mouths (receptors) and a big mouth for one of their favorite “foods.” They are highly addicted to one natural hormone in the big read ocean of blood they live in, the natural hormone cortisol.

The adrenal cortix, a major portion of a small gland that rests above our kidneys, produces cortisol daily. The brain determines the production level of the cortisol. After analyzing the signals that indicate that the fish need more cortisol, the brain sends a second hormone to another part of the brain, which in turns sends a third hormone through the blood to the adrenals. “Boys,” the brain communicates through the second hormone, “The other fish (cells) are complaining out there! They aren't getting their daily cortisol fix. Adrenals, get cracking!”

The daily cortisol fish-food manufacturing product (FMP) is usually 40 milligrams. When the human is healthy (fish are happy) and there is no undo stress to cause a part of the system (other fishes) from “stealing” extra cortisol from the red ocean, or making other fish feel deprived. Deprived fish may start growing more mouths (cortisol receptors) to help them capture their fair share of any cortisol they can find from that big red ocean.

Cortisol (and oxytocin and melatonin) blood levels vary in the blood in a well-known cycle. Cortisol levels are not constant throughout the day. As cells wake up, fish start eating or complaining early, and cortisol levels rise all morning from the tissue requests to the brain, until, after lunch, and the fish are fat and happy, the cortisol levels slowly begin their decline after noon, until evening. Cortisol levels are at their lowest while most of the fish are sleeping. (Note: Higher levels of the melatonin hormone induce sleep).

As an aside, high levels of cortisol fish-food trigger a response from the liver that releases glucose into the bloodstream. These hormones are called “glutocorticoids, or glucose stimulators. Cortisol is the only natural one. It is as if we evolved to "know" that if the fish are hungry and complaining, an immune response is not far behind; and the immune system will require a good supply of glucose to fuel the impending immune cell division. It is curious to note that something keeps glucose levels elevated while we sleep at night, while there is no glucose present from the food. Somehow, both high and low levels of cortisol seem to trigger blood glucose to rise, even at night when cortisol is low.

The budding science of the late 1950s and 1960s illuminated how breast cancer was either caused or exacerbated by estrogens. Estrogens promoted the growth of breast cancer, similar to adrenal fish (cortix) making other "steroid" hormones, including testosterone and estrogens. During this time, well meaning doctors completely reomved the adrenal glands of breast cancer patients to eliminate the supply of estrogen (SAFE USES OF CORTISOL, 3rd EDITION, William Mck Jefferies, MD, 2003). During the “adrenalectomy” procedures, these doctors discovered that the adrenal glands produce more hormones than they initially suspected. They also discovered that the hormone cortisol was so important that its absence would lead to death within 24 hours.

“Cortisol is the only essential hormone,” Jefferies begins his book by telling his readers. “We can do without every other hormone for long periods, but if we are without cortisol, even for a single day or two, we die.”

The experiments with adrenal-less breast cancer patients determined that 40 mg daily of cortisol (as hydrocortisone, the bioidentical equivalent of cortisol), regardless of body weight, would keep these women alive and in reasonably good health. The fish were happy; they didn't care that their favorite food (cortisol) came from Merck pharmaceuticals, rather than their adrenal glands. However, if for some reason the adrenal factory fails to produce cortisol, the fish become angry.

Personal note: This author has a secondary adrenal insufficiency, meaning the factory still works, but became faulty in 2011 due to a series of stressors. This author’s endocrinologist prescribed 30 mg of cortisol as hydrocortisone per day, more in the morning, etc. With his own 25 percent production and 75 percent from Merck, his fish are happy and he feels and looks normal. Life is good.

This author’s mother, Billie Valentine Fonorow, had Rheumatoid Arthritis – which manifested in pain in her fingers and everywhere – all her later adult life, after 1974. After Mayo Clinic received the Nobel Prize for discovering cortisol in the 1950s, Merck first synthesized it, and William mck Jefferies was the resident who administered the very first doses of Merck hydrocortisone to patients in an arthritis ward. They had no idea of what dose to use, and Jefferies became the world expert.

Billie was sent to Mayo Clinic after her diagnosis in the 1970s, and received one cortisone shot. This led to immediate relief, but not a cure. She then moved to Tucson and started to read Linus Pauling's Common Cold Book, which led to her trying 3 grams of vitamin C. She then read Adelle Davis, and found that vitamin C was the only thing that could relieve (but not remove) her arthritis pain. She started taking high doses of vitamin C to mitigate her then life-long pain, and the rest, as they say, is history. Despite having to suffer her entire life with her unhappy fish, she was able to pass down her knowledge of Vitamin C and its healing properties to her son.

However, this author has her genes, and the propensity to have unhappy fish despite his very high vitamin C intake. He was at least 10 years older than his mother was when his fish first became unhappy campers. It is known that the adrenal glands have the highest concentrations of “reduced” (not oxidized) vitamin C of any group of fish (tissues), other than the brain. Vitamin C, by helping the adrenals function, can sometimes make fish happier; however it seems that much of the time, these fish aren't completely satisfied by higher vitamin C alone. Fish are only satisfied if they get their daily cortisol “fix.”

Dr. Jefferies and his team discovered that when you first get the flu, the flu virus interrupts the brain signaling, which turns off the adrenal function, which stops the production of cortisol (SAFE USES OF CORTISOL, 3rd EDITION, William Mck Jefferies, MD).
Our cells running out of Cortisol is what causes that “terrible” feeling when the flu first sets in, which manifests in a fever, chills, shames, flushing, pain, and vomiting. “Help us brain, help us brain... Let’s emit histamines, so other cells around us know there is trouble brewing...” The fish start complaining with everything they can. Dr. Jefferies recommended 100 mg of oral hydro-cortisone at the first onset of the flu to his patients, and then tapering to 50 mg on day 2, and so on. This protocol can cause one to avoid nearly all flu symptoms.

Linus Pauling also wrote that taking vitamin C in high doses might stop or mitigate the severity and duration of the flu. High concentrations of vitamin C are needed by the adrenals, though most people take only the small amount of vitamin C suggested by their doctors and government. This leads to the question: Could taking vitamin C to combat the flu have some connection with the adrenals/cortisol? Jefferies poses this question in his book, as well.
Another important component to mention is that the fishes’ mouths (cortisol receptors) can become oxidized! The fishes’ mouth can become plugged and gagged, causing them difficulty in eating their favorite food. Vitamin C, a strong antioxidant, can save the day by removing the fishes’ gag from its mouth. The newly un-oxidized mouth can again eats is favorite food, cortisol, as long as some of the food is passing by in the big red ocean.

One could ask, what if the fish whose mouths are being gagged (oxidized) are adrenal fishes (tissues)? What if the adrenals cells aren't able to eat their required fish food because their mouths are oxidized?

One could also wonder whether is it possible that because all the fish are gagged, this leads to what looks like a massive body infection. Sepsis is a body infection that leads to frequent hospital deaths. Thanks to professor Paul Malik. MD, we now know that a little fish food (cortisol) can save the day. However, because fish mouths become gagged (oxidized) in severe illness, Dr. Malik’s cure includes vitamin C – a powerful antioxidant that opens up the fish mouths (un-oxidizes the cortisol receptor). With fish now able to eat their favorite food, which is being amply supplied, the human recovers in a few hours. Otherwise, 1000 to 1500 people die every day from sepsis in hospitals, medical centers that for their own economic survival, rarely routinely provide either vitamin C or cortisol to patients.

As mentioned previously, when the fish complain, the brain computes what is needed (how many screaming fish are out there?) and then sends it’s second hormone signals to the adrenals, through the big red ocean, with the current total amount of fish-food necessary to quiet all the fish down (the current quantity of cortisol that has to be produced).

Not often considered, these brain signals may affect other hormones, especially if the fish don't quiet down. The other hormones made in other parts of the adrenal glands are not the real targets of the brain signals, but the production of other adrenal hormones can be affected. When the brain is being bombarded with requests for cortisol, the fish are unhappy, releasing substances telling every other fish they are unhappy, and creating more cortisol mouths to feed. Meanwhile, body defenses rise, fluids build up, mucous build up, an “immune response” takes place; however the big red ocean still doesn't have the fishes’ favorite food. Maybe 40 mg isn't cutting it today, so the brain is getting an extra signal or two... Maybe today is the day the fishes need 50 mg... “Okay adrenals, get busy…overtime request…” But the adrenals are maxed out and cannot make any more cortisol, or they are missing all of the signals, or maybe there is not enough vitamin C. Other parts of the cortix can and does respond, and a hormonal imbalance is created.

In review, the output of the cortisol from the adrenal is usually a set value, e.g. 40 mg, and if some is provided by Merck, the total required is 40 mg and no more gets released into the read ocean. In other words, it is not additive. The body doesn't generally receive a full load from the adrenals PLUS the supply from Merck. Under normal conditions, the Merck food makes fish happy, and the brain signals less to the adrenals, “Slow down boys, all fish are happy.” This is called resting the adrenal fish. A good Merck dose to rest the adrenal fish is between 10 to 30 mg. If we overdose, and give it all from Merck at a high dose greater than the need, say greater than 40mg, the adrenal fish will become lazy, the brain is quiet, the adrenal fish go to sleep, “stop the vendors, we don’t need supplies, lets take a vacation.” This is called shutting down the adrenals, but probably only the fish that make cortisol stop working. Other hormones continue to be made if they can.

Resting the adrenals is a good thing, so the factories are ready to produce, and have excess capacity, if something major happens. You stub your toe! The adrenal fish are ready to go into max fish food production (cortisol) and respond like the champs they are. The adrenals can deal with stress with increased cortisol! We can take what ever the outside world throws at us.

The author's adrenal insufficiency condition is such that he only has a 25 percent adrenal production capacity for cortisol. 75% of his adrenal manufacturing plant has burned down (i.e., 75% of the fish that make cortisol may have been killed).

When a major event hits him, he doesn’t have the way to feed the fish, and boy do they complain. Mayo/Merck and his endocronologist ride in to save the day, with fish food to be taken orally! The symptoms subside; all is well on a high fish food diet. High doses of “steroids” (fish food) flood the red ocean. At the right dosage, fish can be happy in 30 minutes for the next 8 hours. The liver not only knows how to handle cortisol (it is orthomolecular), its fish requires the same fix/food as well!

The brain may be requesting slightly more fish food than some people's cortisol fish in the adrenals can provide to its customers. Signals keep coming to and from the brain; other departments of the adrenal cortix start responding to the adrenal signals from the brain because the brain is becoming desperate (where are those cortisol guys?). The brain starts sending more frequent, stronger, perhaps other hormonal signals down to the adrenals. “Lets go, get with the program.” This is one reason why DHEA hormone production may also burn out. Dr. Jefferies found that DHEA supplementation could be very helpful in his patients (who he is already giving a safe 30 mg daily to rest their adrenals) for the same reasons. It helps to quiet the brain.

Jeffries outlined case study after case study in his book to speak to the benefits of cortisol. Young women in puberty with small breasts, presumably because the erroneous brain signals prompted the production of male hormones, started taking Jefferies' safe adrenal resting dosage of cortisol. This caused their brain to settle down, and their small breasts became normal sized. Jefferies’ protocol has also turned childless couples into parents with 100% success rate! He uses the same formula – keep the fishes happy with about 50% of the daily fish food requirement supplied by Merck.

Big Pharma: How would it make money if everyone is well?
Naturally, a natural fish food (hydrocortisone) isn't going to make a drug company a lot of money over time. One must have something that keeps fish happy, but that can be patented; a kind of super fish food! The “unnatural” glutocortocoid steroids like prednisone, methyl prednisilone, etc. are “concentrated” fish foods, thus different and possibly toxi-molecular forms of fish foods. The liver may not know what to do with these kinds of fish foods, for example. Less is more, so instead of 40 mg of hydrocortisone, Merck can supply 8 mg of methyl prednisilone, and the fish are happy, and the drug is patented. Hydrocortisone as a natural hormone might have been as easily available over-the-counter as DHEA, or melatonin, or progesterone...

If all of the fish are always happy, there would be no need for a wide range of patented “fish poisons” on the market, prescription drugs. If one were to make unhappy fish, and then treat all the symptoms from unhappy fish with patented medication, then one could create a business with enormous profits!

But what if people found out that fish can be happy on the cheap, natural bioidentical fish food? First, it would have to be prescribed, and doctors must be terrified to prescribe it, must be made to believe that a “steroid” is the most dangerous drug a doctor can prescribe! A doctor applauded as the best by U. S. News and World Report shared this with the author.
The basis for the fear that cortisol is dangerous is rooted in very early research when doctors had no idea how much fish food to provide. When they started studying the concentrated, toximolecular forms, such as prednisone, instead of the 10 mg of prednizone (that equals the 40 mg adrenal suppressing dose of hydrocortisone), they gave patients 100-150 mg or more (the functional equivalent of 500+ mg of hydrocortisone). As one could suspect, things went haywire. These old studies are used to scare doctors, and the new studies are suppressed by medical journals. This allows the pharmaceutical industry to maintain its status as the largest profit industry in the world.

Modern life, stress and certain foods can lead to higher level fish food requirements, or false brain signaling; which has been used as the basis for a smear campaign against cortisol, and causes people to become afraid of high cortisol. People under stress should be given a safe level of fish food so that they can help rest the adrenal factory, and avoid adrenal exhaustion from modern life. It may sound paradoxical to treat high cortisol with more cortisol, but the basis of this is to keep the adrenals from going under from exhaustion (over production).

This author believes that if he was a naturopath (ND), and was able to give or prescribe patients’ hydrocortisone, that there would be no pain or illness in any of his patients. Unfortunately, most people cannot get their doctors to provide long-term prescriptions for fish food in the proper dosages.

However, one might argue: If we can give patients enough of the good fish food so that they never complain (even if there is a real virus afoot attacking the body), is that a good idea? Would it be preferred to have no symptoms, no fluids, no mucous, no cough, and breathe normally; even if under a full blown attack of viral pneumonia? Not even have to go to a doctor or hospital?

This author’s bias is that most people who are diagnosed with pneumonia are diagnosed from symptoms caused by unhappy fishes. This author wonders: is there even an infection?
Owen R. Fonorow, Follow #OWENRFONOROW at twitter

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Re: CORTISOL - The Perfect Fish Food

Post Number:#2  Post by Johnwen » Fri Apr 13, 2018 11:18 am

This part seems to go off onto something that your over looking in your fishy analogy.

High and low cortisol both somehow trigger blood glucose to rise,
but why at night when cortisol is at its lowest?? Suggests some kind of curve, or other mechanism.


Ever hear of something called, “Sleep dependent aldosterone release??”

Then ask yourself, “What effect does Aldosterone have on Cortisol and what effect of the these steroids have on the T cells and what is their effect on the immune system??”

Once you find the answer to these then your getting at least your toes wet in the fish’s environment! :?
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Re: CORTISOL - The Perfect Fish Food

Post Number:#3  Post by ofonorow » Fri Apr 13, 2018 8:07 pm

Does Cortisol Harm or Enhance Immunity? (Chapter 7 - Owens 2nd Book https://vitaminccures.com/blog/index.ph ... now-about/)

“We now know that the influenza virus attacks the human body by impairing the production of adrenocorticotropic hormone (ACTH), which, in turn, impairs the production of cortisol, the only hormone that is absolutely essential for life.” – William Mck Jefferies,


Medical doctors are taught to be cautious of prescribing Cortisol-like steroids because of their negative effect on immunity. From my own experience, I now believe that doctors are trained incorrectly. This is yet another example where medical doctors are steered away from a lower cost alternative to newer, more expensive prescription drugs. – William Mck Jefferies



Furthermore, According to world expert endocrinologist William Mck Jefferies, MD,

“Concern regarding the occurrence of respiratory illness in such patients was enhanced by the knowledge that large doses of glucocorticoids (prednisone, hydrocortisone, etc.) could impair resistance to infection while masking the symptoms.

It was, therefore, a finding of some surprise and considerable relief that years passed with patients consistently reporting that they had either no common cold or only very mild attacks. Most of these patients had no symptoms even suggestive of such disorders; but when symptom did occur, a prompt increase in the replacement dosage of glucocorticoid was often followed by a disappearance of the symptoms with recurrence when the dosage was returned to maintenance levels. During this time, other members of the patient’s families seemed to have the usual quota of respiratory illnesses, to the absence of such illness in the patients could not be attributed to lack of exposure to the viruses.

An additional reassuring observation was that when patients with adrenal insufficiency developed respiratory infections, the increase in dosage of replacement gluccorticoid did not cause an increase in complicating bacterial infections such as sinusitis or bronchitis, and unless a bacterial complication developed, antibiotic therapy was not necessary” (Jefferies, pg 127 and 128).

The possibility that cortisol might enhance resistance to infection was so contrary to the well-known effect of its impairment that it was initially considered with skepticism. Yet, a review of the medical literature revealed an impressive amount of evidence that physiological amounts of glucotrticoid (e.g., cortisol) can have a protective effect against infection.


Before that research about low cortisol at night, while interesting, this topic is secondary. (Since my blood sugar and sodium are "text book", doesn't that mean my aldosterone is good - why I have secondary adrenal insufficiency, and not primary? https://en.wikipedia.org/wiki/Aldosterone

Question: Do you disagree that cortisol elevates blood glucose?

Of course It does, that is why it is called a Glucocorticoid. And wouldn't such an evolutionary response to the yelling fishes be the perfect preparation for the future immune battle? Higher blood sugar would provide the immune systems the fuel the'll need in their massive endeavor to produce new immune fishes? (And wouldn't the flu evolve which could turn off this perfect response?)

So instead of what I am told by all MDs, that high steroids "turn off the immune system," is not the truth is the opposite? It is the perfect preparation for the immune battle? What better preparation would there be?


But lets focus on whether or not it is good to "suppress symptoms." Please assume with me, that all symptoms can be turned off by quieting the fishes by satisfying their cortisol fix.

Lets take Gastroesophageal reflux disease (GERD), as an example that might be problematic to turn off all pain.

One one hand, no one would suffer the pain of GERD when they eat, so any stomach acid damage to their lower esophagus would never be noticed by the symptom of pain alone. Good or bad thing?

Probably bad, as ulceration bleeding would be the first indication that an ulcer had formed at the bottom of the throat from stomach acid.

On the other hand, since there would be no pain, no one would take any stomach ant-acids, stomach acid would remain normal, the upper esophagul sphincter would close tight, and there might never be any underlying GERD.

Certainly no one would take a proton acid blocker (did I hear purple pill, Nexium or Prilosec?) which risks blindness, depression and blocks the stomach absorption of vitamin C!
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Re: CORTISOL - The Perfect Fish Food

Post Number:#4  Post by Johnwen » Fri Apr 13, 2018 10:48 pm

Of course It does, that is why it is called a Glucocorticoid


The name Glucocorticoid (glucose + cortex + steroid) is composed from its role in regulation of glucose metabolism, synthesis in the adrenal cortex, and its steroidal structure.


https://en.wikipedia.org/wiki/Glucocorticoid

It’s also because it binds to the glucocorticoid receptor which is present in almost all parts of the body!

https://en.wikipedia.org/wiki/Glucocorticoid_receptor

So your statement that Cortisol increases blood sugar is correct! However extended and long term use does come with a price! As exampled in the first wiki with this, in case you miss it!

The name "glucocorticoid" derives from early observations that these hormones were involved in glucose metabolism. In the fasted state, cortisol stimulates several processes that collectively serve to increase and maintain normal concentrations of glucose in blood.

Metabolic effects:

Stimulation of Gluconeogenesis, in particular, in the liver: This pathway results in the synthesis of glucose from non-hexose substrates, such as amino acids and glycerol from triglyceride breakdown, and is particularly important in carnivores and certain herbivores.

Enhancing the expression of enzymes involved in Gluconeogenesis is probably the best-known metabolic function of Glucocorticoids.

Mobilization of amino acids from extra hepatic tissues: These serve as substrates for Gluconeogenesis.

Inhibition of glucose uptake in muscle and adipose tissue: A mechanism to conserve glucose

Stimulation of fat breakdown in adipose tissue: The fatty acids released by lipolysis are used for production of energy in tissues like muscle, and the released glycerol provide another substrate for gluconeogenesis.

Excessive glucocorticoid levels resulting from administration as a drug or Hyperadrenocortism have effects on many systems. Some examples include inhibition of bone formation, suppression of calcium absorption (both of which can lead to osteoporosis), delayed wound healing, muscle weakness, and increased risk of infection. These observations suggest a multitude of less-dramatic physiologic roles for glucocorticoids.


Or you might want to look into this;

Theoretically, this mechanism can increase the risk for type 2 diabetes, although a causative factor is unknown. Since a principal function of cortisol is to thwart the effect of insulin—essentially rendering the cells insulin resistant—the body remains in a general insulin-resistant state when cortisol levels are chronically elevated. Over time, the pancreas struggles to keep up with the high demand for insulin, glucose levels in the blood remain high, the cells cannot get the sugar they need, and the cycle continues.


http://www.todaysdietitian.com/newarchi ... 9p38.shtml

Or you can go here if you don’t want to believe the foodies!

https://www.livestrong.com/article/4190 ... d-glucose/

So I hope you can see that continued and long term use of supplementing or taking cortisol outside over the bodies normal levels or circadian rhythm or outside of periods of stress can cause some serious problems through out the body! Think of cortisol like liquor in people who still can produce their own cortisol. To much can do harm in many, many ways and those who don’t produce their own cortisol should take it at the appropriate times and at levels their body requires. To much too often and one is just creating more problems.
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Re: CORTISOL - The Perfect Fish Food

Post Number:#5  Post by ofonorow » Sat Apr 14, 2018 3:39 am

johnwen wrote:So I hope you can see that continued and long term use of supplementing or taking cortisol outside over the bodies normal levels or circadian rhythm or outside of periods of stress can cause some serious problems through out the body!


ABSOLUTELY WRONG.,, wait a minute, you qualified your statement with (outside normal circadian rhythm or outside of periods of stress.. he he he)

What we are learning - from my unintended hospital experiment (that has sent the FDA on a "wild goose chase", not really, I just don't care what they find, because it led to an important disovery that the RIGHT STUFF (bioidentical hydrocortisone) IS AS SAFE AS VITAMIN C, PROBABLY SAFER, SO LONG AS IT IS TAKEN IN THE SAFE PHYSIOLOGICAL RANGE OF 10 mg to 30 mg DAILY.. This is a fact. (Now, don't throw any study my way that is of an analog, hmm except maybe the ones by Pinkus showing he can cure and treat arthritis with 10 mg of prednisone or less...) Seriously, any toxicity study of any gluctocorticoid EXCEPT hydrocortisone is NOT GERMANE. Confuses the issue... Forget about it.

Now focused on hydrocortisone (bioidentical to cortisol) and you find something, okay ,and yes, under stress taking more there will be issues.. High blood sugar can affect eyesight (so I have started taking carnosine eye drops and pills.. another story for another day) Hell the high doses may feed my adrenal fishes so well, my adrenals may no longer require Merck and I won't need it... But I will take the safe dose Jefferies prescribes, even to pregnant women, all my life and SO SHOULD EVERY PERSON OVER AGE 40 ON PLANET EARTH.. No harm what-so-ever can come from those non adrenal shutdown dosages, and certainly less harm than vitamin C at almost any dose. This is nuts, finding out that the "most dangerous drug in the world" is safer than vitamin C - AT THE CORRECT DOSE.

And then my endo tells me - cortisol keeps you awake at night. Duh! There could be military implications here... I haven't been asleep much since I entered the hospital last Tuesday... I feel like superman, probably better than I have felt in my life, but certainly better than I have since 2010/2011 !!!!!!!!!!
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Re: CORTISOL - The Perfect Fish Food

Post Number:#6  Post by ofonorow » Mon Apr 16, 2018 7:19 am

Did I mention crystal clear brain function - feeling of wide awake and totally conscious? Bye bye brain fog. Did I forget to mention that all that increase in drainage and pus coming out of my naval, forcing the mesh removal issue, has almost dried up since I started Titrating cortisol? (Overview of the titration: I take a 50 mg oral hydro-cortisone dosage in the morning.. Then I wait for the start of the chest/pneumonia symptoms to reappear, e.g. the wheeze, the cough, the start of the pain and cramping, etc.. At that point, I take 20 mg cortisol, dutifully record in the brilliant (premium) medsafe app, wait 30 minutes to get into my blood stream... Symptoms are gone.. As soon as the symptoms reappear... Do over, another 20 mg...

Well the periods between titrations are getting longer (and the cortisol dosages I need are getting lower) that stave off what ever is causing the underlying stress. (I am also on a home infusion of an iv antibiotic.) Last night things seemed to break, as I got through almost the entire night without having to titrate.

And note, we are about to replace the very FIRST post in this topic with the latest, 2nd Draft of the FISH article. And the first post will keep being updated to the latest version, at least until we send it out to Townsend..

Now, this is the following conversation with a "close relative", ( a 29 year old body builder) after I told her to take 5 mg of cortisol in the morning... he he he. In this discussion, the FISH article I am referring to is the first post (post #1)


close - but confused 28 year-old - relative wrote:Isn’t cortisol a stress hormone? Why do I need to give myself more of that again? When I started at [deleted] I was already feeling overly stressed at [deleted] most of the time which is partly why I left. For someone like you who has adrenal insufficiency it makes sense but why would I want to take it? I don’t mean to sound combative or anything I’m just confused.

Love,


Great question!

Before I answer your question(s) below, the "FISH" paper I sent last night for help with editing is what I hope will help answer the same question in everyone's minds who consider cortisol a "stress" hormone to be avoided at all costs. It would be a big favor if in addition to editing, you also STUDIED it at the same time. Lets try to make a hard thing clearer, so that you completely and clearly understand.

Everything that has happened to me has been to reveal this truth..

You cannot change people's minds... But truth is truth.

Yes Cortisol IS the stress hormone, but IT DOESN'T CAUSE STRESS. It helps the body resist and adapt to stress.

We used to have to run from Sabre tooth tigers. That was stress. In modern life, there is a lot of pseudo stress.. No real need to pump up the cortisol supply.. However, your brain thinks stress is stress, e.g., say your boss yells at you. The brain then says to the adrenals - make more cortisol.. and high levels are not good. Granted.

Providing your body with extra (low levels) of cortisol turns out to be miraculous. And a 5mg dose is a great start. The key discovery is that when you rest your adrenals, by giving them small amounts, it is not only safe, (safer than vitamin C - the bioidentical hormone only) cortisol can and should be given to pregnant women. Infertile couples - 100% conception rate when they get the right small amount of cortisol (hydrocortisone). The small amounts, by resting the adrenals, have a mountain of positive effects.

On Sun, Apr 15, 2018 at 10:34 PM, specific answers to the questions


Isn’t cortisol a stress hormone?​
The hormone doesn't CAUSE stress, it is the body's evolved mechanism for dealing with stress - think running from a sabre tooth tiger.​ Only "bad" when more than 40 mg is in circulation. (5 - 30mg can safely be given to pregnant women.)

Why do I need to give myself more of that again?​
Taking 5 mg (really 10 to 30mg) is the PERFECT way to relieve stress.. Please review the FISH article I sent for review with this in mind. Your little fishes (trillions of cells) start complaining if they cannot get their daily supply of cortisol. Cortisol is the ONLY absolutely essential hormone. (You can live long periods without the myriad of other hormones.) And as the FISH paper points out, if you don't have cortisol for 24 hours - you die. Much faster than you die of scurvy (e.g., 28 days without vitamin C).​ Most people therefore are making (at least some) cortisol every day. Proof? They are alive. You are lucky persson. You have a good set of adrenals making your own cortisol. I have to rely on MercK and Pfizer. (In my case, I die if the supply of hydrocortisone is cut off.... But this is all ordained from above - to teach me... Thank you late co-founder and brother Steve!)

When I started at xxxxI was already feeling overly stressed at xxxx most of the time which is partly why I left.
And knowing what I (we) know now, a little extra cortisol could have helped you a great deal - by resting your adrenals. (Of course, you still have to learn how to relieve the mental pseudo-stress caused by modern life. i.e. meditation. Not let things get under your skin.. Have a lot of great sex, etc...)​

For someone like you who has adrenal insufficiency it makes sense but why would I want to take it?​
Not only sense, I would die in 24-48 hours. Hopefully, I am making the case why you absolutely want to take the 5 mg (at least) and probably more if you still feel under stress. And please review and study the FISH paper.​

I don’t mean to sound combative or anything I’m just confused
.​ Your not! Great question. It is impossible to change minds, and most people are brainwashed the cortisol (steroids) are evil, bad, to be avoided at all costs, are the most dangerous "drugs" doctors prescribe..

I was terrified of "steroids" too, after those 2, 10 day Intensive Care stays back in 2011.. I was afraid to take the steroids my primary care gave me, which she said may help me stay out of the hospital a 3rd time.. Remember, I went for 120 grams of vitamin C IV - didn't help. Nothing helped. (Dr. Levy recommended solu cortef.. that helped temporarily, but neither of us really knew why.) Then, I took one little pill. RELIEF!! What the hell? Led me to the definitive book SAFE USES OF CORTISOL, 3rd EDITION, by William Mck Jefferies, MD. This is the book that explains EVERYTHING. In fact, I am contacting the publisher offering to convert it to Kindle form as a public service..​
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Re: CORTISOL - The Perfect Fish Food

Post Number:#7  Post by ofonorow » Thu Apr 19, 2018 7:36 am

Bump. I just posted a full revision of the very first post #1
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Re: CORTISOL - The Perfect Fish Food

Post Number:#8  Post by ekaitz » Thu Apr 19, 2018 8:20 am

I don't see it. Sure HC its useful for people with tested hypocortisolism or adrenal inssuficiency, but I'd be well sure of this FIRST before considering external HC. Cortisol catabolizes organs tissue, muscle and skin, it accelerates skin aging. You highly need it under inflammation, so the less you need it the better. But more important, the more sensitive your receptors 'll be to it the better. You´d want intermittent blocking from time to time to keep or improve resensitization. This is the opposite to taking it externally!! so 3 points,

1. Avoid/kill any source of chronic stress, keep blood glucose curve under control.
2. Do smart periods of cortisol blocking, make those fish hungry for short periods of time. You'll regain efficiency, more effect with less producing = less taxing on adrenals.
3. Use controlled HD doses as Jefferies suggested when low working adrenals and imbalance on cortisol/dhea had been diagnosed.

It would be a good test to try that low physiological jefferies dose using a cgm for 2 weeks and see what happens with blood glucose.


PD. So this was the mysterious greatest suppression.
Last edited by ekaitz on Thu Apr 19, 2018 4:03 pm, edited 1 time in total.

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Re: CORTISOL - The Perfect Fish Food

Post Number:#9  Post by ofonorow » Thu Apr 19, 2018 2:58 pm

will address, good to debate, but it is all a lie. Everything you are worried about... Cortisol is SAFER than vitamin C, safe and important for pregnant women. No time. The definitive book if you want the truth is SAFE USES OF CORTISOL, 3rd Edition, William Mck Jefferies.
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Re: CORTISOL - The Perfect Fish Food

Post Number:#10  Post by ekaitz » Thu Apr 19, 2018 4:22 pm

I have that book since long time ago, No doubt its an amazing read nowadays because it demystifies all the fearmongering modern medicine has been pushing all the time against it. Think about it, cortisol is the bodys best natural anti-inflammatory defense. Its the chronic untamed inflammation the evil to target, thats why cortisol is a hell of an important hormone even with its sides. But general promoting for any healthy person to use it in daily basis, like vitamin C, thats another story, and I strongly disagree with that. I don't mean some individuals wont benefit from it, like having weak or not properly function adrenals.. or even a healthy person under puntual or specific scenario, temporal stress overload.. that is OK. But definitely not as a supplement, like, ie. vitamin c, k2, mg.- etc. What a healthy person could do is intermittent cortisol blocking for improving efficiency which is the hormetic response. Same mindset as with fasting from time to time. You need to think in "inverse" mode to understand endocrinology.

So I don't think its correct to say one thing is safer than the other, HD and vitamin C are two different whole animals.

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Re: CORTISOL - The Perfect Fish Food

Post Number:#11  Post by ofonorow » Thu Apr 19, 2018 7:51 pm

Again, no time to digest, but will come back as this is my favorite subject these days..

Found this - haven't even viewed.. Dr Jefferies video


https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&uact=8&ved=0ahUKEwjchLid3sfaAhVD54MKHSNyB2gQtwIIPDAC&url=https%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3DyIrwVIPpxtU&usg=AOvVaw21bylItdn8ihnKsq5pQZBt

Wait there is more - you can get hydrocortisone without prescription over the counter! Since 1979
https://www.uspharmacist.com/article/appropriate-use-of-nonprescription-hydrocortisone

And there is more.. liposomal cortisol
https://www.ncbi.nlm.nih.gov/pubmed/9463804
Can you say "skin cream"
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Re: CORTISOL - The Perfect Fish Food

Post Number:#12  Post by ofonorow » Mon Apr 23, 2018 9:27 pm

bump 3rd draft posted at the top. Minor edits - putting things back
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Re: CORTISOL - The Perfect Fish Food

Post Number:#13  Post by ofonorow » Mon Apr 23, 2018 10:22 pm

Many discoveries emanating from my Addisonian condition. I AM DOSING OFF I AM DOSING OFF.. Eureka! After 3 weeks (of almost constant cortisol dosing).. Once the infection was quelled with ONE PILL of vancomycin, the need to take cortisol around the clock went away, and now, around 11:30 I can hardly keep my eyes open. Good night and good mania into the future. LOVE

R truckers running all night going to want a little cortisol?
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Re: CORTISOL - The Perfect Fish Food

Post Number:#14  Post by ofonorow » Fri May 18, 2018 7:15 am

I participated in an experiment where I was deprived of exogenous cortisol for 24 hours. This experience, viewed as an experiment, supports my contention that a human body without cortisol experiences pain – without any other reason needing to be present.

In review, I am diagnosed with a secondary adrenal insufficiency, and under normal (no-stress) conditions, my body produces 10 mg of cortisol out of the 40 mg that the adrenals in most people normally produce. If I take 30 mg of exogenous cortisol as the bio-identical hydrocortisone, (usually 15 mg in the morning, 10 mg at lunch and 5 mg a dinner) I appear to be a normal human being.

During my incarceration, my stress levels were substantial. Not only were my stress levels up because I was being deprived of cortisol/hydrocortisone, the one hormone absolutely required for life, (e.g., death results in 24-48 hours if there is no cortisol in the blood stream), there was also stress that my “family” had me incarcerated. Stress had already been elevated from a bout of influenze type A, because of the issues of the infected hernia mesh and the diagnosed but untreated dental infections.

There is no way to know how much cortisol I required to deal with all the stress, I checked myself into a hospital to find out with my endocrinologists. During that hospital visit, it was determined the 50 mg hydrocortisone/every 8 hours was the current and proper dose. I was given the unusual prescription for 50 mg oral hydro-cortisone/3 X daily, because 2 of the 4 hydrocortisone (Solu-cortef) IV pushes in the hospital had failed.

I began writing on a piece of paper after I realized I was being purposefully deprived of cortisol/ hydrocortisone. The following transcribed record is the pain and other symptoms that I experienced starting at 4:30 a.m., or approximately 5-8 hours after my last hydro-cortisone dose. By 6:00 a.m., when my other medications were administered, I realized that my deprivation of hydrocortisone was on purpose.

Here is the transcribed record (page 1) of my pain and other symptoms as I felt them:


April 27 Statement Owen Fonorow
4:30 a.m. Record of Symptoms and Pain
History (Yesterday) – Arrived a Good Sam 2-3 p.m. Given water, so far no food
16 witnesses (including paramedics and nurses) that I was no threat.
I am in a new room (4011) with a monitor and I was forcefully drugged by IV/push against my willl.
Stopped Prescription meds removed around 5 p.m. Yesterday

Experiencing..
Head Ache
Eye Pain
Neck Pain
Back Pain
Eye Pain
Sore Throat
Back Shoulder Pain
Shakes
Lower Rib Pain
Cough
Trembles

Asked for water and to be taken to the bath room

Dull Ache under Eyes

I have asked for Vitamin C and Hydrocortisone
I am Addison disease-like and require hydro-cortisone to live.
(Not a hospital setting) They are not monitoring me other than vitals.

Mouth, Feet Hurt
Cramp Left Abdomen under rib
Right Side of Throat Sore
Chesty Cough Worsening
Loss of Consciousness
Feeling like Blacking Out
Tooth Ache
Sore Mouth
Pain Inside Mouth, Teeth on Either Side
Yawning Hurts Abdomen
Sore Throat Getting Worse
Neck Swelling
Hard to Swallow

Need physiological dose of cortisol

Harder to talk – Sore Throat

The are recording none of this.

Right Chest Pain

Asked to see the Endocrinologist – past 2 hours

Pain in Lower back, both sides, during breathing
Dizziness
Lips Chapped
Tremors/Shakes
Hand Tremors (6:30 a.m.)
Sore Throat
Eyes Ache
Cough
Chest Pain While Coughing
Pain Behind Teeth
Cough with Mucous Erupts with Talking
Dull Headache Back of Head Between Ears
Sore Throat were “Tonsils” (were) part of Throat
Shortness, Difficulty Taking Breaths, Hard to Expand Lung

.

Image
The ordeal continued and more pain recorded on the back of the page.
Page 2
Dr. Grobbe told [my wife] that relooking at blood work showed I was "toxic"
I told her that I felt fine.
My wife (?) fearful called Paramedics
6 responded. I asked them to call police. I called my attorney
Attorney ...

My civil rights are being violated
I am Addison's Disease-like patient...
My legally prescribed medications are being kept from me
I am a diabetic, yet I have not been given food
I refused treatment and have not given my family doctor
Remember to call Blue Cross/Blue Shield. (Never consented or signed anything)
Unknown IV push against my will
I asked for, but was not given a phone call

Head Ache
Flush Red Face
Hard to Drink Water Mouth Swelling
Pain in Right Chest
Pain Back of Neck Left Side

Food arrived!

Difficulty Swallkwing - Pain - Hard to Eat
Teeth Hurt Chewing - Soar Throat
Kidney Pain
Back Muscle Right
Chest Pain
Very Sore Throat
Hard to Breath Diaphram
Upper Back Pain
Finger and Joint
Feet Burning


Image

The above is the record of pain and symptoms as i felt them while being deliberately deprived of my legally prescribed prescription medicine hydrocortisone. Towards the end, I began to fear for my life, as I was totally under the hospital's control.

Although against my will, this "experiment", the first in a human being unable to make enough of the Steroidal Anti-inflammatory hormone cortisol, proves that that main thesis in the FISHES paper (Topic #1) is correct: The lack of Cortisol evokes inflammation and other symptoms, usually associated with infection, without any other cause being present.
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Re: CORTISOL - The Perfect Fish Food

Post Number:#15  Post by ofonorow » Thu May 24, 2018 6:19 am

Rereading my favorite book, SAFE USES OF CORTISOL, 3rd Edition, by William Mck Jefferies (which is available as an ebook- see http://www.vitaminc.foundation/forum/viewtopic.php?f=3&t=13884). The idea is record some relevant quotes from the book as they may support or not support the FISHES thesis - i.e., that the human body simply inflames when cells/tissues are not getting their natural steroidal anti-inflammatory hormone cortisol.

But first, apparently others recognized the military application of "steroids" during World War II. Jefferies was a Flight Surgeon during world war II, and writes this about the Nazi's possible use of steroids


Jeffries wrote:In the fall of 1941, just before Pearl Harbor, requests were made to the National Research Council by the medical department of the Army and Navy for a large supply of the hormones of the adrenal cortex, because it was believed that they might be of value in the event of military conflict. Interest in these hormones was heightened by a rumor that pilots of the German Luftwaffe were injected with adrenal cortical extract and that this enabled them to fly with ease at altitudes of 40,000 feet or more. During the war, twenty-tow laboratories in the United States were attempting to prepare hormones of the adrenal cortex, but by 1945, after interest in potential military use of adrenocortical hormones had subsided, only the laboratories of the Mayo Foundation and of Merck & Co., Inc persisted in this search."

(SUOC, Background, Page 4, History)


In my case, the clarity taking hydrocortisone at night, the lack of brain fog, the memory improvement, the feeling of a "super brain" from taking the hormone to control pain throughout the night was striking. The nighttime effects should be studied for its military applications, and perhaps it is, except for the cloud that has been placed on the use of high dose "steroids. A cloud that Jefferies's book was written to dispel . (Of course, being awake most of the night, and apparently not needing the normal sleep, meant that there was a lot of time to send emails :? )

As I mentioned, after the mouth/dental pain subsided and I was able to reduce the hydrocortisone so as to not take it at night, I started to sleep through the night. At that point, the feeling of "super brain" became more "normal brain". It was a very noticeable decline. (I'm sure others on the outside observing me had a different opinion about what was going on. But the improvement of brain function, and the lack of need for sleep, are important and should be studied.)

The memory improvement and clarity makes me wonder if high dose hydrocortisone, at least short-term use, will become an effective treatment for dementia and/or Alzheimer's?

More quotes from the Jefferies book


Jeffereies wrote:Introduction to the first edition, xvii

One of the the aspects of this type of therapy that has strained its credibility is the weid variety of pathologic disorders that are benefited. It is difficult to believe that one therapeutic agent could help so many conditions.

[there is] Evidence that physiologic dosages of cortisone, or hydrocortisone may improve resistance to viral infections, in contrast the known harmful effects of pharmacologic dosages that decrease such resistance.

In over one thousand patient years of experience with the dosages described, none of the harmful potential of large pharmacologic dosages has been encountered.


Jefferies wrote:Preface to the 2nd Edition, vii

The dynamic nature of cortisol responsiveness undoubtedly contributes to this problem, since a dosage that is necessary for survival at times of increased stress may cause serious side effects if continued after the stress has subsided or if it is given at times when stress is not present. Similarly, if the dosage is changed capriciously, more harm than benefit may ensue.


Jefferies wrote:Preface to the First edition xiii

Employment of safe dosages on a proper schedule has demonstrated a a promising potential in patients with gonadal dysfunction with or without infertility, rheumatoid arthritis, allergic rhinitis, asthma, recently recognized autoimmune disorders such as hyperthyroidism and diffuse goiter, chronic thyroiditis, and diabetes mellitus, and common clinical problems such as functional hypoglycemia, hirsutism, acne and chronic cystic mastitis. The relative freuency and clinical significance of low adrenal reserve as a cause for unexplained chronic fatigue or functional hypoglycemia and a a possible contributing factor in many allergies provides another area of therapeutic promise.
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