AA rescues cardiomyocytes in embryonic stem cells

This forum will focus on analyzing recent clinical studies of vitamin C.

Moderator: ofonorow

ofonorow
Ascorbate Wizard
Ascorbate Wizard
Posts: 15819
Joined: Tue Nov 22, 2005 3:16 pm
Location: Lisle, IL
Contact:

AA rescues cardiomyocytes in embryonic stem cells

Post Number:#1  Post by ofonorow » Sun Jul 15, 2012 3:30 am

http://www.ncbi.nlm.nih.gov/pubmed/22735182
Ascorbic acid rescues cardiomyocyte development in Fgfr1(-/-) murine embryonic stem cells.


Harvard had reported that only ascorbic acid (out of 880 substances tested) converted mouse stem cells into heart muscle cells. http://www.sciencedaily.com/releases/2003/04/030401073122.htm

I do not claim to understand this abstract completely, but there are quite a few very interesting statments, e.g.

Among them, only the reduced form of vitC, l-ascorbic acid, was able to recover beating cell differentiation in Fgfr1(-/-) mESC.


In the attempt to elucidate the mechanism of action of vitC on Fgfr1(-/-) mESC, we analyzed several parameters related to the intracellular redox state, such as reactive oxygen species content, Nox4 expression, and superoxide dismutase activity. The results did not show any relationship between the antioxidant capacity of vitC and cardiomyocyte differentiation in Fgfr1(-/-) mESC. No correlation was found also for the ability of vitC to modulate the expression of pluripotency genes.


Then, we tested the hypothesis that vitC was acting as a prolyl hydroxylase cofactor by maintaining iron in a reduced state.
Owen R. Fonorow
HeartCURE.Info
American Scientist's Invention Could Prevent 350,000 Heart Bypass Operations a year

Return to “Clinical Studies”

Who is online

Users browsing this forum: No registered users and 3 guests