What I´m aiming at, is to find a logical way to understand, and perhaps also overcome?, my neighbours mental fixation with him believing in the possibility of him having Ehlers-Danlos syndrome, just because two of his relatives are diagnosed with it, in spite of the obvious visible facts the he does not have any hypermobility of joints or any particularly stretchable skin...(whether his relatives do, I don´t know). My logic so far is that chronically low levels of vitamin C and other vit./minerals do eventually cause several wellknown diseases, so one is better off by supplementing while being disease-free, but once a particular disease has occurred, one might also regain health by supplementation...however...my neighbours fixation with him possibly having a genetic disease makes my argumentation fall flat to the ground, since no amount of supplementation in the world can do anything to a genetic disease, apart from reducing symptoms perhaps...(and he relies heavily on medical-doctors for disease in general, and with genetic diseases in particular!...) however...I might perhaps further the virtues of megadosing with vitamins with the logic that although most E-D.-syndromes are inherited autosomal dominant, two of them, the Kyphoscoliosis type 6, mentioned in the link above provided by Majkinetor, and the hypermobility type, type 3, are also inherited autosomal recessive, so if he is by chance a carrier, he would still benefit enormously from megadoses of vitamin C, since his hypothetical then only 50% capacity for producing a particular type of collagen due to the inability of this possibly affected gene to produce functional collagen, necessary for joint-stability and other functions, will be 50% more vulnerable to ascorbic-acid deficiency compared with the capacity of a healthy person, since only one gene remains to produce this type of collagen when ascorbic acid is present...say if a healthy person ingests a couple of oranges or a gram-tablet of C, and gets temporary relatively "higher than normal" levels of C in the blood, the amount of proper collagen produced during the time when 'higher than normal' amounts of C was present would be 50% higher in a healthy individual compared with a "carrier" where one defective collagen-producing gene is present...an otherwise disease-free "carrier" of an 'E.D.-syndrome recessive gene' would simply put need 50% more C than a healthy person, or the same amount present for 50% longer time, to attain the same amounts of properly produced collagen as a healthy person has, thus leading to the same overall structural integrity as a person with two intact genes has...? ...in other words, a person carrying a defective recessive E.D.-gene would need more vitamin C than a non-carrying person...?
While looking into this enigma, looking among other things for a sort of "time-line" of when in ancient history the different mutations occurred that caused various proteins to become necessary as "vitamins", I found a for me completely new one, one which I´ve never heard of before...where the methylation-process apparently can be disturbed by one or two mutations, called MTHFR-mutations....leading up to a whole range of difficult-to-understand conditions... it can be read about here:http://www.methyl-life.com/index.html