http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract
found an 88% improvement in vascular dementia in men who reported taking both vitamin E and C.
RESULTS: In a multivariate model controlling for other factors, a significant protective effect was found for vascular dementia in men who had reported taking both vitamin E and C supplements in 1988 (odds ratio [OR], 0.12; 95% CI, 0.02 to 0.88). They were also protected against mixed/other dementia (OR, 0.31; 95% CI, 0.11 to 0.89). No protective effect was found for Alzheimer's dementia (OR, 1.81; 95% CI, 0.91 to 3.62). Among those without dementia, use of either vitamin E or C supplements alone in 1988 was associated significantly with better cognitive test performance at the 1991 to 1993 examination (OR, 1.25; 95% CI, 1.04 to 1.50), and use of both vitamin E and C together had borderline significance (OR, 1.18; 95% CI, 0.995 to 1.39). CONCLUSIONS: These results suggest that vitamin E and C supplements may protect against vascular dementia and may improve cognitive function in late life.
The following report sumarises later John Hopkins research that found that "Use of vitamin E and C supplements in combination reduced Alzheimer's prevalence by about 78% and incidence by about 64%, the researchers report. " Note they save the most important news until last, "The study suggests that higher doses may offer protection against Alzheimer's disease when taken together. "
Vitamin E and C Combo Reduces Alzheimer's Risk
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Print 01.19.2004 @04:49 PM
By Dwayne Hunter
Combining vitamin E and C supplements could be a simple way to reduce the risk of Alzheimer's disease.
Studies have shown that antioxidant vitamins can protect the brain against damage caused by free radicals and other byproducts of metabolism.
Neurons are especially sensitive to such damage, which is believed to contribute to neurological diseases such as Alzheimer's.
Peter Zandi of Johns Hopkins University in Baltimore, Maryland and colleagues have now found that combining vitamin E and vitamin C supplements can dramatically reduce the risk of Alzheimer's
Use of vitamin E and C supplements in combination reduced Alzheimer's prevalence by about 78% and incidence by about 64%, the researchers report.
The researchers assessed supplement use and the prevalence of dementia and Alzheimer's disease in 4,740 people 65 and older between in 1995 to 1997.
They then followed up between 1998 and 2000.
They found 200 Alzheimer's cases between 1995 and 1997 and 104 new cases during their follow-up.
Looking at the effects of supplement use, they divided subjects according to their vitamin E and vitamin C intake.
Participants were classified as vitamin E users if they reported taking supplements of vitamin E totaling more than 400 IU. They were categorized as vitamin C users if they reported taking supplements totaling at at least 500 micrograms of ascorbic acid.
The researchers found the greatest reduction in both prevalence and incidence of Alzheimer's disease amongst those who used individual vitamin E and C supplements in combination, with or without an additional multivitamin.
The study found no appreciable association with the use of vitamin C alone, vitamin E alone or vitamin C and multivitamins in combination.
The current recommended daily allowance for the vitamins, the researchers say, is 22 IU for vitamin E and 75 to 90 micrograms for vitamin C.
The study suggests that higher doses may offer protection against Alzheimer's disease when taken together.
The research is published in the January issue of The Archives of Neurology (read abstract).
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Note this report says micrograms and means milligrams.