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tangy wrote:ofonorow @ Please see the below....
However, there were some drawbacks to Dr. Leung’s protocol. The major disadvantage was the amount of Vitamin B5 his test subjects had to take in order to see significant results – up to 5 to 10 grams of pantothenic acid a day. At this level, a significant number of patients experienced gastric or stomach problems and disturbances such as bloating.
However, there was a way around this problem… By adding a totally natural amino acid – L-Carnitine – the amount of pantothenic acid could be substantially reduced and still be effective. Since L-Carnitine plays a crucial role in fatty-acid metabolism, by adding it as a supplement fatty acids could be transported into the mitochondrial matrix and broken down. Pantothenic acid and L-Carnitine work hand in hand in helping to turn acne causing fatty acids into cellular energy instead of ugly pimples!
Since the L-Carnitine reduced the amount of Vitamin B5 needed to achieve results, stomach problems were avoided.
http://www.pantothen.com/m/research.html
tangy wrote:ofonorow @ Is this the article http://orthomolecular.org/library/jom/1 ... 2-p099.pdf ?
Acetyl CoA Important for Cholesterol and Steroid Biosynthesis
Acetyl CoA is the first step in the body’s synthesis of Cholesterol. Cholesterol is then used to make all steroidal hormones. Many of the steroidal hormones are made by the adrenal gland, so it is very logical that B5 deficiency can result in a syndromes called adrenal failure, or the inability to synthesis steroidal hormones such as Cortisol. See my previous article on Adrenal Fatigue for more information about this syndrome.
Jeffrey Dach wrote:
Article by Lit-Hung Leung on Co-Enzyme A
I first became aware of the use of Vitamin B5 (also called pantothenic acid) as a treatment for acne from an article by Lit-Hung Leung (1997). In this article, Dr Leung explains that acne can be reduced or eliminated with the use of Vitamin B5, also called pantothenic acid.
How does it work?
Pantothenic acid is a major component of Co Enzyme A (see diagram above). CoA is used at the cellular level for fatty acid oxidation and in many other biochemical reactions in the cell. Taking additional B5 increases the amount of Coenzyme A available for use in the cell. The more Co-Enzyme A, the more fatty acids can be metabolized, which means they are oxidized or burned up as energy production. CoEnzyme A is actually a Pantothenic Acid molecule attached to an ADP molecule (see diagram above, ADP=adenine triphosphate). ADP is widely available throughout cellular biochemistry as the currency of energy in the cell.
Jeffrey Dach wrote:
What is Pantethine?
2/17
Pantethine Courtesy of Wikimedia Commons Note two B5, Pantothenic Acid Molecules attached with the two sulfur molecules
(S) in the center. Pantethine is made of two Vitamin B5 molecules linked together with two sulfurs (S) in the center (see below
diagram).
It is well known that the Beta Oxidation of Fatty Acids depends on CoA. If there is a deficiency of Acetyl CoA in the body, oxidation of fatty acids will slow down, and the skin becomes oily resulting in acne. Increasing the amount of Acetyl CoA available speeds up the metabolism of fatty
acids which are then used for energy production. Taking the vitamin B5, pantothenic acid is the easiest way to increase acetyl Co A and increase rate of fatty acid metabolism. Dr Leung’s Dosage is Rather Large Dr. Leung gave his acne patients rather large doses of 5-10 grams of Pantothenic Acid a day with considerable improvement in their acne. He reported success with this regimen.
Reducing or Eliminating Acne with Pantethine and L Carnitine
Using the modified Leung B5 protocol with Pantethine 750 mg with 250 mg of L Carnitine three times a day, we have noted excellent success rates in reducing or eliminating acne. An added advantage is a good cosmetic result with smaller pore size and smoother skin. The vitamins are safe with no adverse side effects noted.
Case: A College Student with Acne
A college student under my care was making preparations for her upcoming wedding when she noticed some new acne lesions on her face. We immediately began the Pantethine and L-Carnitine. Her acne cleared up immediately, and she was quite pleased. By now, we have a number of satisfied patients who have used this program to clear up acne. I myself have used the program and can report that it works quite well.
Also Used for Weight Loss
Since this anti-acne regimen is essentially a fat burning protocol, it is also useful for weight loss.
No Adverse Side Effects
Unlike Accutane which may have serious adverse side effects. vitamin B5 have little or no adverse side effects.
I started B5 about 3 months ago and was taking about 20 grams (20,000 mg) daily to clear up my acne. I took this amount for about 3 weeks when I started to notice the shedding. It wasn't massive but enough to concern me. So I stopped the B5. My acne began to return but I maintained it with vitamin A. The hair shedding slowed but did not stop completely. A few weeks later I suffered a huge breakout of acne on my face so I panicked and began taking the B5 again but this time only taking 5 grams per day. Two weeks later my hair began shedding a lot!! I was so depressed. So I began my research into B5 hairloss. Google seemed to have mostly useless information....so I went on to Google Scholar, which has all the studies and medical literature. And I found the answer....
I found this study about mice being treated with Pantothenic Acid (B5) for some sort of nervous system disorder. It is somewhat unclear as to why the mice are being treated, as the full study is not shown unless you pay for the website. But what is clear is that these mice developed alopecia but when Inositol was added, the hair loss stopped. Here is the study. http://www.cabdirect.org/abstracts/1941 ... 189307C294
zarfas wrote:eDOC wrote:BTW, I don't Google, make up or read others work. What I post is based on my clinical experiences and knowledge.
eDOC!!
thanks Edoc, Im still dubious,I was dubios about 10g vit C, but I understood the MOA and I saw changes in people taking lots of grams of VitC
EDOC
you think my dad, who is type 2 diabetic AND has A-fib should take 3+ grams of B5?
zarfas wrote:
thanks for the help!!
True, and I never took DMSO seriously until reading about your cases as spread throughout this forumPS: Owen never took it seriously till he read about Dr. Leung and his work.........
Inositol is a B-vitamin-like nutrient found naturally in whole grains, beans, nuts, and fruits. It is also made by the body and is available as a dietary supplement. There are nine types of inositol occurring in nature. Two forms, myo-inositol and D-chiro-inositol, have specific functions in our cells.
Butt Pucks" How do you make them sweet without sugar...stevia?
ofonorow wrote:
I have already lost 4 inches around my waist.
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