Just reading this obituary about Jerome. http://articles.orlandosentinel.com/2013-05-06/news/os-obit-jerome-sullivan-20130506_1_heart-disease-heart-attacks-iron Ever since I read his 1981 Lancet article, I have believed in his theory about excess iron and still do, but not for the heart. I never heard him say nor have I read in his papers mention of Vitamin C (or lysine or proline). As far as I know, there was never to my knowledge any mention of the additional mechanism of chronic mechanical stress creating cracks in the endothelium of coronary arteries at bifurcations that precipitates the Lp (a), apo (a) repair cascade.
It was not until I got a stent in 2015 for what would have otherwise been a widow-maker lesion in my proximal LAD that I realized the value of Pauling therapy and the failure of a nearly zero level of stored iron (that I maintained personally for 30 years) to stop atherosclerosis in the heart ONLY (my peripheral vessels are clear).
Forgetting for a moment the bowel tolerance limits of oral ascorbate, what is the minimal amount of oral intake of ascorbate that will produce optimal (but temporary) elevations of the blood levels? From what I have read, it should be more optimal to take 2 gm of ascorbate and the same amount of lysine every three hours or so, instead of a larger amount less frequently because of the rapid clearance from the blood stream.
Funny you should ask... The exciting new cancer research has redoubled our efforts to understand blood concentrations and oral vitamin C intake.
For the cancer-stem cell killing effects - looks like 1 gram every 2 hours (or 12 grams daily) - is the minimum dosage.
A 1 g oral dose of AA can raise plasma AA to 130 μmol/L within an hour and such doses at intervals of about two hours throughout the day can maintain ~230 μmol AA/L
Self-reported daily intake varied from 0 to 20 g/day. The plasma AA levels ranged from 11.4 to 517 μmol/L
and correlated well with the reported intake.
Cheryl A Krone, John A Ely, Journal of theNew Zealand Medical Association, 23-August-2002, Vol 115 No 1160,
Glycohaemoglobin and ascorbic acid)
This is the white paper about cancer patient dosing we are working on.
https://vitamincfoundation.org/pdfs/Can ... ePaper.pdf
For me personally, 9,000 mg every 12 hours worked, but the new knowledge, from Hickey/Roberts, that if we simulate animals and take smaller amounts throughout the day, has the same basic effect but less vitamin C is needed.
I didn't know of Jerome, but even though men don't menstruate, red blood corpuscles die after a limited time... What happens to these dead RBCs? The iron would have to be somehow recycled and stored after RBC death.